Document Detail


Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10.
MedLine Citation:
PMID:  3478817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sphingolipid activator protein SAP-1 is required for the enzymatic hydrolysis of GMI ganglioside and sulfatide. The gene coding for SAP-1 was previously mapped to human chromosome 10 using monospecific antibodies prepared against SAP-1 in synteny analysis of somatic cell hybrids. In this study, we used a cDNA probe for SAP-1 and in situ hybridization to regionally localize the SAP1 gene to the long arm of chromosome 10, region q21-22. Additional mapping data using cell hybrids containing partial chromosome 10 and skin fibroblasts with trisomy 10p are consistent with the in situ hybridization mapping results.
Authors:
F T Kao; M L Law; J Hartz; C Jones; X L Zhang; N Dewji; J S O'Brien; D A Wenger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Somatic cell and molecular genetics     Volume:  13     ISSN:  0740-7750     ISO Abbreviation:  Somat. Cell Mol. Genet.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-11     Completed Date:  1987-12-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8403568     Medline TA:  Somat Cell Mol Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  685-8     Citation Subset:  IM    
Affiliation:
Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Banding
Chromosome Mapping*
Chromosomes, Human, Pair 10*
DNA / genetics
Glycoproteins*
Humans
Karyotyping
Nucleic Acid Hybridization
Proteins / genetics*
Saposins
Sphingolipid Activator Proteins
Grant Support
ID/Acronym/Agency:
HD02080/HD/NICHD NIH HHS; HD18983/HD/NICHD NIH HHS; NS08682/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/PSAP protein, human; 0/Proteins; 0/Saposins; 0/Sphingolipid Activator Proteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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