| Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction. | |
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MedLine Citation:
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PMID: 21428685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, a noninvasive method for determining regional myocardial contractility, using an animal-specific finite element (FE) model-based optimization, was developed to study a sheep with anteroapical infarction (Sun et al., 2009, "A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm," ASME J. Biomech. Eng., 131(11), p. 111001). Using the methodology developed in the previous study (Sun et al., 2009, "A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm," ASME J. Biomech. Eng., 131(11), p. 111001), which incorporates tagged magnetic resonance images, three-dimensional myocardial strains, left ventricular (LV) volumes, and LV cardiac catheterization pressures, the regional myocardial contractility and stress distribution of a sheep with posterobasal infarction were investigated. Active material parameters in the noninfarcted border zone (BZ) myocardium adjacent to the infarct (T(max_B)), in the myocardium remote from the infarct (T(max_R)), and in the infarct (T(max_I)) were estimated by minimizing the errors between FE model-predicted and experimentally measured systolic strains and LV volumes using the previously developed optimization scheme. The optimized T(max_B) was found to be significantly depressed relative to T(max_R), while T(max_I) was found to be zero. The myofiber stress in the BZ was found to be elevated, relative to the remote region. This could cause further damage to the contracting myocytes, leading to heart failure. |
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Authors:
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Jonathan F Wenk; Kay Sun; Zhihong Zhang; Mehrdad Soleimani; Liang Ge; David Saloner; Arthur W Wallace; Mark B Ratcliffe; Julius M Guccione |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biomechanical engineering Volume: 133 ISSN: 1528-8951 ISO Abbreviation: J Biomech Eng Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-24 Completed Date: 2011-07-29 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: United States |
Other Details:
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Languages: eng Pagination: 044501 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of California-San Francisco, CA 94121, USA. jwenk1@me.berkeley.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Finite Element Analysis* Male Myocardial Contraction* Myocardial Infarction / physiopathology* Sheep Stress, Mechanical* Ventricular Dysfunction, Left / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL063348/HL/NHLBI NIH HHS; R01 HL063348-12/HL/NHLBI NIH HHS; R01 HL077921-06/HL/NHLBI NIH HHS; R01 HL084431-04/HL/NHLBI NIH HHS; R01 HL086400-02/HL/NHLBI NIH HHS; R01-HL-63348/HL/NHLBI NIH HHS; R01-HL-77921/HL/NHLBI NIH HHS; R01-HL-84431/HL/NHLBI NIH HHS; R01-HL-86400/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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