| Regional left ventricle mechanical asynchrony in patients with heart disease and normal QRS duration: implication for biventricular pacing therapy. | |
| | |
MedLine Citation:
|
PMID: 12710315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
LV electromechanical delay results in asynchronized contraction. However, it is not known if the presence of cardiac diseases without QRS prolongation may result in inter- or intraventricular asynchrony. This study investigated the occurrence of systolic mechanical delay in different regions of the LV in patients with underlying heart diseases and normal QRS duration. Tissue Doppler imaging (TDI) was performed in 141 patients (age 63.7 +/- 11.5 years) with underlying heart diseases (82% had ischemic heart disease) and 92 normal healthy volunteers (age 63.9 +/- 9.8 years) based on the four-basal and four-mid-segment model by apical views. Of these, 124 patients had normal QRS duration (< or = 120 ms) while 17 were prolonged due to LBBB or intraventricular conduction defect. Patients with normal QRS duration had significantly lower peak myocardial isovolumic contraction velocity (IVCM), sustained systolic velocity (SM), and prolonged time to peak IVCM and SM in almost all myocardial segments when compared to controls. The time to peak IVCM (basal lateral vs basal septal segment: 61.0 +/- 29.4 vs 53.3 +/- 24.1 ms, P < 0.005) and SM (basal lateral vs basal septal segment: 174 +/- 44 vs 154 +/- 36 ms, P < 0.001) was further delayed in the LV free-wall segments. Mechanical delay was also evident in the LV free-wall segments in patients with preserved or impaired systolic function, in patients with or without previous myocardial infarction, and in patients with prolonged QRS duration. Patients with prolonged QRS had a higher prevalence of LV free-wall delay of > 50 ms (47 vs 24%, chi-square = 4.6, P < 0.05). In conclusion, the presence of cardiac diseases was characterized by LV global mechanical delay; and, intraventricular asynchronized contraction characterized mostly by further mechanical delay in the free-wall region. These changes occur even in those with normal QRS duration. |
| | |
Authors:
|
Cheuk-Man Yu; Hua Yang; Chu-Pak Lau; Qiong Wang; Shelley Wang; Linda Lam; John E Sanderson |
Related Documents
:
|
17261425 - Left ventricular geometry and renal function in hypertensive patients with diastolic he... 9377955 - Lack of left ventricular dysfunction associated with sustained exposure to hyperlipidem... 15297785 - Changes of the cardiac architectures and functions for chronic hemodialysis patients wi... 20722555 - Impact of amlodipine or ramipril treatment on left ventricular mass and carotid intima-... 22350625 - Right hepatic artery thrombosis in an essential polycythemia vera patient following pan... 3803125 - Quantitative assessment of pelvic ileal reservoir emptying with a semisolid radionuclid... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pacing and clinical electrophysiology : PACE Volume: 26 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-04-24 Completed Date: 2003-07-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
|
Languages: eng Pagination: 562-70 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Department of Medicine, Queen Mary Hospital, University of Hong Kong. cmyu@cuhk.eda.hk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cardiac Pacing, Artificial
/
methods* Case-Control Studies Echocardiography, Doppler* Electrocardiography* Female Heart Diseases / physiopathology* Heart Rate Humans Male Middle Aged Myocardial Contraction / physiology Systole / physiology Ventricular Dysfunction, Left / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of isoproterenol testing following radiofrequency catheter ablation of accessory pathways i...
Next Document: Role of vagal control in vasovagal syncope.