Document Detail

Regional intrapulmonary gas distribution in awake and anesthetized-paralyzed man.
MedLine Citation:
PMID:  264858     Owner:  NLM     Status:  MEDLINE    
Intrapulmonary distribution of ventilation/unit lung volume was studied in 28 volunteers in the sitting, supine, or right lateral decubitus position, either awake or anesthetized-paralyzed and mechanically ventilated. We found significant differences between the awake state and anesthesia-paralysis with mechanical ventilation in 1) intrapulmonary gas distribution, and 2) the vertical gradient of regional functional residual capacities for the subjects in the lateral decubitus position, but not for those in the sitting and supine positions. The effect of increasing the tidal volume on distribution of ventilation was significantly different 1) between the three body positions for a given state, and 2) between the two states for a given body position. The data suggest thoracoabdominal mechanics are different in the three body positions and that anesthesia-paralysis and mechanical ventilation may cause a different pattern of expansion of the respiratory system than spontaneous breathing in the awake state.
K Rehder; A D Sessler; J R Rodarte
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  42     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-04-30     Completed Date:  1977-04-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-402     Citation Subset:  IM    
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MeSH Terms
Functional Residual Capacity
Paralysis / chemically induced,  physiopathology*
Pulmonary Diffusing Capacity
Tidal Volume
Ventilators, Mechanical
Wakefulness / physiology

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