Document Detail

Regional homogeneity changes in patients with neuromyelitis optica revealed by resting-state functional MRI.
MedLine Citation:
PMID:  20621555     Owner:  NLM     Status:  In-Process    
OBJECTIVE: Resting-state brain activity in neuromyelitis optica (NMO) patients can give clues to the pathophysiology of the disorder, and may be helpful in diagnosis; however, it has been less explored using functional MRI (fMRI). In the current study, we used a regional homogeneity (ReHo) method to investigate NMO-related modulations of neural activity in the resting state.
METHODS: Resting-state fMRIs acquired in 17 NMO patients as well as in 17 age- and sex-matched normal controls were compared. Kendall's coefficient of concordance was used to measure the regional homogeneity. Correlative analyses were performed to explore the relationship between the expanded disability status scale (EDSS), disease duration and ReHo in regions with significant group differences.
RESULTS: Comparing the NMO group with the healthy controls, we found ReHo decreased in extensive brain regions, including the left anterior cingulate, left medial frontal gyrus, left posterior cingulate, right precuneus and right middle temporal gyrus; and increased in the right inferior frontal gyrus.
CONCLUSIONS: These results demonstrate that neural activity in the resting state is changed in patients with NMO.
SIGNIFICANCE: The present study reveals clear abnormalities of NMO patients in the baseline activities that have not been well detected, and further improves our understanding of the neural substrates of cognitive impairment in NMO patients.
Peipeng Liang; Yaou Liu; Xiuqin Jia; Yunyun Duan; Chunshui Yu; Wen Qin; Huiqing Dong; Jing Ye; Kuncheng Li
Related Documents :
6201225 - Effect of electroconvulsive therapy on serum myelin basic protein immunoreactivity.
19943735 - Negative effect of hypopituitarism following brain trauma in patients with diffuse axon...
8489845 - Brain atrophy in neurodegenerative diseases. quantitative and qualitative ct analysis.
1149465 - The relation of visuospatial dysfunction to digit span performance in patients with cer...
19685075 - Identification of blastocystis hominis isolates from asymptomatic and symptomatic patie...
20491705 - Serum albumin level predicts initial intravenous immunoglobulin treatment failure in ka...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  122     ISSN:  1872-8952     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of core and NS4B synthetic peptide-based immunoassays for the detection of hepatitis C vi...
Next Document:  Use of pharmacotherapy for insomnia in child psychiatry practice: A national survey.