Document Detail

Regional histaminergic potencies in rabbit systemic circulation.
MedLine Citation:
PMID:  1936898     Owner:  NLM     Status:  MEDLINE    
1. Regional activity of histamine was studied in various rabbit arteries, including segments of the aorta, aortic branches, branchout regions and arteries to fore and hind limbs by dose-response experiments. 2. Local histaminergic potencies were found to be heterogenceous. Circular and longitudinal smooth muscle responsivity in the aorta increased in the distal direction; aortic branches have their own histaminergic response characteristics beginning from their branchouts. Paired arteries (right and left subclavia, renal and iliac) possess matching histaminergic activities. 3. The observed characteristics of the responses suggest predetermined distribution of histaminergic activities along systemic circulation which may be regulatory in the distribution of blood.
H Gürbüz; H O Onaran; T A Bökesoy
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  22     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-06     Completed Date:  1991-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  659-61     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, Ankara University, Sihhiye, Turkey.
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MeSH Terms
Arteries / drug effects*
Drug Resistance
Histamine / pharmacology*
Receptors, Histamine / drug effects,  physiology
Vasoconstriction / drug effects
Reg. No./Substance:
0/Receptors, Histamine; 51-45-6/Histamine

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