Document Detail


Regional heterogeneity in the contractile and potentiating effects of neuropeptide Y in rat isolated coronary arteries: modulatory action of the endothelium.
MedLine Citation:
PMID:  1364848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Neuropeptide Y (NPY) induced a concentration-dependent contraction of isolated rings of proximal epicardial (PC) and distal intramural (DC) coronary arteries of the rat, with an EC50 of ca. 1 x 10(-7) M. The NPY-induced contraction at 3 x 10(-7) M was significantly smaller in PC than DC arteries: 34% vs. 55% of the 125 mM K(+)-induced response, respectively. 2. NPY (2 x 10(-8) M) increased the sensitivity to noradrenaline (NA) and 5-hydroxytryptamine (5-HT) more in PC (4.2 and 2.8 fold, respectively) than in DC arteries (2.2 and 1.4 fold, respectively). The maximal contractile response to NA and 5-HT was increased more in DC (43% and 29%, respectively) than in PC arteries (20% and 12%, respectively). 3. Removal of the endothelium increased the sensitivity and maximal response to NPY as well as the spontaneous myogenic tone in PC but not in DC arteries. NPY had no relaxing effect on PC and DC arteries submaximally contracted with 10(-6) M prostaglandin F2 alpha, suggesting that spontaneous rather than stimulated release of endothelium-derived relaxing factor (EDRF) depresses the contractile action of NPY in PC arteries. 4. The results indicate a heterogeneity in the contractile and potentiating action of NPY in rat coronary arteries depending on size or location in the coronary circulation.
Authors:
D Prieto; S Benedito; U Simonsen; N C Nyborg
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  102     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1995-01-05     Completed Date:  1995-01-05     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  754-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Aarhus, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / drug effects*,  physiology
Endothelium, Vascular / physiology*
Male
Neuropeptide Y / pharmacology*
Nitric Oxide / secretion
Norepinephrine / pharmacology
Rats
Rats, Wistar
Serotonin / pharmacology
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 10102-43-9/Nitric Oxide; 50-67-9/Serotonin; 51-41-2/Norepinephrine
Comments/Corrections

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