Document Detail

Regional hemodynamic effects of antihypertensive renomedullary lipids in conscious rats.
MedLine Citation:
PMID:  6746083     Owner:  NLM     Status:  MEDLINE    
Renomedullary tissue has been proposed to exert an antihypertensive endocrine-like action. The antihypertensive polar renomedullary lipids (APRL) and neutral renomedullary lipids (ANRL) are potential mediators of this action. We evaluated the blood pressure and regional hemodynamic responses to APRL administered peripherally (i.v.) and to the central nervous system (CNS) in normal rats and rats with sinoaortic deafferentation (SAD) to remove baroreflex buffering. Rats were chronically instrumented with Doppler flow probes for measurement of mesenteric, renal, and hind-quarter vascular resistance, with arterial pressure and intravenous catheters, and with lateral cerebroventricular cannuli for intracerebroventricular (i.c.v.) administration. Intravenous APRL (0.01 to 1.0 micrograms) produced a dose-dependent decrease in blood pressure, tachycardia, and dilation of all vascular beds studied. The dose-response relationships were shifted to the left in SAD animals. APRL administered i.c.v. had no effect on intact or SAD rats. Pressor and regional vasoconstrictor responses to norepinephrine, angiotensin, and vasopressin were markedly reduced in SAD animals during constant infusion of APRL. In a second group of conscious SAD animals instrumented for blood pressure and heart rate measurements, intravenous ANRL (500 micrograms) decreased both arterial pressure (-45 +/- 16 mm Hg) and heart rate (-50 +/- 16 bpm). When given i.c.v., however, ANRL (10-100 micrograms) had no significant effect on resting blood pressure or heart rate. These studies suggest that APRL and ANRL produce no significant cardiovascular effects that are mediated through the CNS. However, both lipids are potent depressor agents, and APRL exhibits a strong peripheral vasodilator action and nonspecifically reduces reactivity to vasoconstrictor agents.
J E Faber; K W Barron; A C Bonham; R Lappe; E E Muirhead; M J Brody
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  6     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-09-14     Completed Date:  1984-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  494-502     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Brain / drug effects
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hemodynamics / drug effects*
Kidney Medulla / metabolism*
Lipid Metabolism
Lipids / administration & dosage,  pharmacology*
Rats, Inbred Strains
Vascular Resistance / drug effects
Grant Support
Reg. No./Substance:

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