Document Detail


Regional hemodynamic abnormalities in overweight men. Focus on alpha-adrenergic vascular responses.
MedLine Citation:
PMID:  2547397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure, forearm hemodynamic data, and red blood cell (RBC) cation transport measurements were obtained in 27 men with body mass indexes (BMI) greater than 26.6 kg/m2 and 21 men with BMI less than 26.6 kg/m2. Subjects with higher BMI had significantly higher systolic and diastolic pressure measured both noninvasively and invasively, P less than .02-.001. Baseline forearm blood flow (FABF) was substantially higher in the heavier subjects, P less than .02, whereas forearm vascular resistance (FAVR) levels were not different, P greater than .10. Despite the higher baseline forearm blood flow, the high BMI group displayed a greater rise in flow, P less than .01, in response to a regional phentolamine infusion, an index of vascular alpha-tone. Results of multiple regression analysis suggested that overweight was indirectly correlated with vascular alpha-tone via a relationship with arterial plasma norepinephrine concentration, a marker of sympathetic drive, and bumetanide-sensitive RBC Na+-K+ cotransport activity. These data indicate that in overweight men (1) higher FABF is not fully counter-balanced by lower FAVR; (2) increased vascular alpha-tone contributes to the altered flow-resistance relationship and thereby to the elevated blood pressure; and (3) greater sympathetic drive and Na+-K+ cotransport activity may explain the elevated vascular alpha-tone.
Authors:
B M Egan; N J Schork; A B Weder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  2     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-13     Completed Date:  1989-09-13     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  428-34     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
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MeSH Terms
Descriptor/Qualifier:
Blood Vessels / physiopathology
Body Weight
Forearm / blood supply*
Hemodynamics
Humans
Male
Middle Aged
Norepinephrine / pharmacology
Obesity / pathology,  physiopathology*
Phentolamine / pharmacology
Receptors, Adrenergic, alpha / physiology*
Regional Blood Flow / drug effects
Vascular Resistance
Grant Support
ID/Acronym/Agency:
HL01353/HL/NHLBI NIH HHS; R01 HL34464/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 50-60-2/Phentolamine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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