| Regional glucose consumption and oxygen supply in the isolated perfused working rat heart. | |
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MedLine Citation:
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PMID: 6534144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using 2-Deoxyglucose as a tracer, regional myocardial metabolic rate of glucose (MMR GL) has been determined in an isolated perfused working heart preparation. Under control conditions (n = 8) mean glucose consumption of the left ventricular wall amounted to 1.17 +/- 0.24 mumol X g-1 X min-1, which was about twice that of the right ventricular wall. There was an inhomogeneous distribution of MMR GL in the left ventricular wall with the endocardial rates exceeding the epicardial ones by about 20%. Isoprenaline (1.25 micrograms X L, n = 9) induced an increase in heart rate and a decrease in cardiac output. Under these conditions mean glucose consumption increased by about 20%, and a redistribution of MMR GL was observed in the left ventricular wall. As, in the preparation used, only glucose was offered as an exogeneous substrate, this redistribution should reflect a similar redistribution of myocardial energy metabolism and, therefore, muscular tension developed in the different layers of the ventricular wall. |
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Authors:
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W Breull; W Küsters; R Naberschnig |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 180 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1984 |
Date Detail:
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Created Date: 1985-05-30 Completed Date: 1985-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 721-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glucose / metabolism* Heart / drug effects, physiology Isoproterenol / pharmacology Male Myocardium / metabolism* Oxygen Consumption* Perfusion Rats Rats, Inbred Strains Regional Blood Flow Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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