Document Detail


Regional gastric mucosal blood flow after parietal cell vagotomy in dogs.
MedLine Citation:
PMID:  3738748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we used the recently validated H2 clearance method to perform endoscopic measurements of gastric mucosal blood flow (MBF) in anesthetized dogs before and after parietal cell vagotomy (PCV). Under resting conditions, MBF in the gastric corpus before PCV was 72 +/- 5 ml/min/100 gm. This was not altered significantly at 4, 8, or 16 weeks after PCV, and there were not significant long-term changes in MBF on the greater or lesser curvatures of the corpus individually. Before PCV infusion of pentagastrin (8 micrograms/kg/hr) elicited increases in corpus MBF to 104 +/- 4 ml/min/100 gm, accompanied by increases in gastric acid output from resting levels of 2.1 +/- 0.9 to 38.6 +/- 2.4 mEq/hr (p less than 0.001). PCV significantly reduced pentagastrin-stimulated acid secretion by 50%, and secretory inhibition was accompanied by significant reductions in pentagastrin-stimulated MBF in the corpus. Pentagastrin did not alter antral MBFs before or after PCV. In summary PCV does not elicit significant long-term changes in resting MBF in different regions of the gastric corpus, and PCV significantly diminishes increases in acid output and corpus MBF that are normally stimulated by pentagastrin. These observations suggest that alterations in gastric MBF after PCV may be attributable to alterations in acid secretion.
Authors:
D I Soybel; S W Ashley; Z Y Yan; R A Swarm; L Y Cheung
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  100     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Gastric Acid / secretion
Gastric Mucosa / blood supply*,  secretion
Male
Pentagastrin / diagnostic use
Postoperative Period
Regional Blood Flow
Stimulation, Chemical
Time Factors
Vagotomy, Proximal Gastric*
Grant Support
ID/Acronym/Agency:
1F32AM07178-02/AM/NIADDK NIH HHS; 1F32AM07511-01/AM/NIADDK NIH HHS; AM 35191-01/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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