| Regional fat loss from the thigh in obese women after adrenergic modulation. | |
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MedLine Citation:
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PMID: 2894247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beta-adrenergic stimulation and alpha 2-adrenergic inhibition increase lipolysis from fat cells. Twenty-eight obese women were placed on a calorie-restricted diet and one of five treatments was applied to one thigh three to five times per week for four weeks: (1) isoproterenol injections; (2) cream containing colforsin (forskolin), aminophylline, and yohimbine; (3) yohimbine cream; (4) colforsin cream; or (5) aminophylline cream. The opposite thigh was treated with a placebo (injection or cream). The treated thighs lost significantly more girth after treatment, both by injection and by cream. No adverse reactions were attributable to either the cream or the injections. It is concluded that local fat reduction from the thigh can be safely accomplished. |
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Authors:
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F L Greenway; G A Bray |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical therapeutics Volume: 9 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1987 |
Date Detail:
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Created Date: 1988-04-11 Completed Date: 1988-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 663-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, UCLA School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Administration, Cutaneous Adrenergic alpha-Antagonists / administration & dosage, therapeutic use* Adrenergic beta-Agonists / administration & dosage, therapeutic use* Clinical Trials as Topic Double-Blind Method Female Humans Injections Lipolysis / drug effects Obesity / drug therapy*, metabolism Phosphodiesterase Inhibitors / administration & dosage, therapeutic use Thigh |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Agonists; 0/Phosphodiesterase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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