| Regional expansion during myocardial ischemia predicts ventricular fibrillation and coronary reocclusion. | |
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MedLine Citation:
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PMID: 9612389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary ventricular fibrillation (VF) complicating acute myocardial infarction is associated with occluded infarction-related arteries. The relationship between VF during ischemia and spontaneous coronary reocclusion was analyzed in 48 anesthetized pigs submitted to 48 min of coronary ligation and 6 h of reflow. Reocclusion was associated with ischemic VF (6 of 11 animals with VF but only 6 of 37 without it had reocclusion) but not with reperfusion arrhythmias, the size of the ischemic area, the magnitude of electrocardiogram changes or contractile dysfunction during ischemia, or the severity of intimal injury at the occlusion site. The increase in end-diastolic length in the ischemic region during coronary occlusion was associated with ischemic VF (15 min after occlusion, end-diastolic length was 116 +/- 2 and 111 +/- 1% of baseline in animals with or without presenting subsequent VF, respectively) and was retained by multiple logistic regression analysis as the only independent predictor of ischemic VF and reocclusion. Thus ischemic VF is strongly associated with an increased rate of spontaneous coronary reocclusion during subsequent reperfusion. Acute expansion of ischemic myocardium appears as a prominent determinant of both ischemic VF and reocclusion. |
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Authors:
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J A Barrabés; D Garcia-Dorado; M A González; M Ruiz-Meana; J Solares; Y Puigfel; J Soler-Soler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 274 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-06-24 Completed Date: 1998-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1767-75 Citation Subset: IM |
Affiliation:
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Servicio de Cardiología, Hospital General Universitari Vall d'Hebron, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / etiology, physiopathology* Electrocardiography Female Male Myocardial Ischemia / pathology*, physiopathology Prognosis Swine Ventricular Fibrillation / complications, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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