Document Detail

Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain.
MedLine Citation:
PMID:  9134187     Owner:  NLM     Status:  MEDLINE    
We determined regional concentrations of excitatory and inhibitory amino acids in pentylenetetrazol (PTZ) kindling and kindled rat brains in order to investigate the mechanisms responsible for the PTZ kindling process and kindled state. Compared with control rats, PTZ kindling rats had significantly higher concentrations of aspartate in the striatum and the temporal cortex 24 h after the 14th injection of PTZ. Glutamate and GABA concentrations were also significantly higher in the brainstem of PTZ kindling rats 24 h after the 14th injection of PTZ. These findings suggest that the striatum and temporal cortex may participate in a pathway for propagation of the PTZ kindling process, and that the brainstem may be a primary site of PTZ kindling epileptogenesis or a part of the pathways for propagation. On the other hand, the concentrations of amino acids in PTZ kindled rats and controls did not differ 4 weeks after the 14th injection. This suggests that the alterations we detected in amino acid metabolism are not related to retention of the PTZ kindled state, and that some other mechanism for it must exist.
H Sejima; M Ito; K Kishi; H Tsuda; H Shiraishi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain & development     Volume:  19     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-30     Completed Date:  1997-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Department of Pediatrics, Shimane Medical University, Izumo, Japan.
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MeSH Terms
Alanine / metabolism
Amino Acids / metabolism*
Aspartic Acid / metabolism
Brain Chemistry / physiology
Glutamic Acid / metabolism
Kindling, Neurologic / physiology*
Neural Inhibition / physiology
Rats, Wistar
Seizures / chemically induced,  metabolism,  physiopathology
Taurine / metabolism
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Convulsants; 107-35-7/Taurine; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid; 56-41-7/Alanine; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid

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