| Regional effects of myocardial ischemia on epicardially recorded canine first heart sounds. | |
| | |
MedLine Citation:
|
PMID: 8175520 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To determine whether focal changes in myocardial material properties are important in determining the response of first heart sound acceleration amplitude and frequency to myocardial ischemia, cardiac vibrations were simultaneously recorded from ischemic and nonischemic regions of canine epicardium by use of ultralight acceleration transducers. Cardiac acceleration and hemodynamics were recorded before and 5 min, 15 min, 1 h, and 2 h after left circumflex coronary artery occlusion. Peak-to-peak amplitude declined transiently in the nonischemic zone during early occlusion (P < 0.05) but was not decreased at any time in the ischemic myocardium. The median frequency of first heart sound vibrations in the ischemic region increased 31% within 5 min after occlusion (P < 0.01) and remained elevated for 2 h (P < 0.05). Nonischemic zone frequency was not statistically different from baseline at any time point. The disparate regional response of first heart sound vibrational frequency to myocardial ischemia suggests that propagating mechanical transients and myocardial contractile acceleration, rather than resonant vibrations, produce the first heart sound. |
| | |
Authors:
|
J C Wood; M P Festen; M J Lim; A J Buda; D T Barry |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 76 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1994 Jan |
Date Detail:
|
Created Date: 1994-06-06 Completed Date: 1994-06-06 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 291-302 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / physiology Dogs Electrocardiography Fourier Analysis Heart Rate / physiology Heart Sounds / physiology* Hemodynamics / physiology Male Myocardial Infarction / physiopathology Myocardial Ischemia / physiopathology* Phonocardiography Signal Processing, Computer-Assisted |
| Grant Support | |
ID/Acronym/Agency:
|
HL-34691/HL/NHLBI NIH HHS; NS-01701/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of increasing the tidal volume of smoke breaths on smoke-induced lung dysfunction.
Next Document: Cerebral pressure-flow and metabolic responses to sustained hypoxia: effect of CO2.