Document Detail

Regional distribution of glutathione peroxidase and Glutathione-S-transferase in adult and premature human retinas.
MedLine Citation:
PMID:  3335428     Owner:  NLM     Status:  MEDLINE    
The activities of glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GSH-S-tase) were investigated in adult and premature human retinas. The measurements were done in the vascular and avascular regions of premature retinas at gestational age of 22-33 weeks and in the central, mid-peripheral, and far peripheral regions of mature retinas from the age of 1 month to 73 years. Among the premature infants, those who survived for greater than 24 hours were supplemented with alpha-tocopherol (vitamin E) on a periodic basis. The vascular and avascular regions of premature retinas had higher activities of GSH-Px when compared to the central and far peripheral regions of mature retinas. Infants surviving more than 24 hr had higher activities of GSH-S-tase in the avascular region than infants who survived less than 24 hr. Survival did not affect either enzyme activity in the vascular regions. Mature retinas showed a decrease in GSH-Px specific activity with age, but no age-related changes in GSH-S-tase were observed. These data demonstrate that premature infants are born with relatively high levels of GSH-Px and GSH-S-tase.
M I Naash; J C Nielsen; R E Anderson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  29     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-23     Completed Date:  1988-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-52     Citation Subset:  IM    
Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
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MeSH Terms
Child, Preschool
Glutathione Peroxidase / metabolism*
Glutathione Transferase / metabolism*
Infant, Newborn
Infant, Premature / metabolism*
Middle Aged
Retina / enzymology*
Tissue Distribution
Reg. No./Substance:
EC Peroxidase; EC Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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