Document Detail


Regional distribution of citrate synthase and lactate dehydrogenase isoenzymes in the bovine heart.
MedLine Citation:
PMID:  2750536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gradients of oxidative and glycolytic enzyme activities in the heart were studied by comparing samples taken from 10 locations from each of six bull hearts, within 30 min after slaughter. Citrate synthase (CS) was used as a marker of the oxidative potential and the lactate dehydrogenase (LD) subunits II and M as markers of aerobic glycolytic and anaerobic glycolytic potential respectively. CS activity in the ventricular tissue was greater than that of the right atrium, and no difference was found between the right and left ventricles. The left ventricular free wall had higher CS activity at the base than at the apex of the heart. Both the H and M subunit activities of LD increased in the following order: right atrium, right ventricle, ventricular septum, left ventricle. The left ventricular free wall showed higher H and M subunit activities at the base than at the apex. Within the left ventricular wall at the base, subendocardium had higher H and M subunit activities than subepicardium. The M subunit constituted the highest fraction of LD in the subendocardium and in the papillary muscle of the left ventricle. In conclusion, this study suggests that there are metabolic differences along both the radial and the longitudinal axes of the left ventricle and across the ventricular septum. These differences indicate that the greatest cellular stress, both aerobic glycolytic and anaerobic glycolytic in nature, occurs within the subendocardium at the base of the left ventricle and in the left ventricular papillary muscle.
Authors:
C Sylvén; L Lin; A Kallner; F Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  136     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-15     Completed Date:  1989-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  331-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Huddinge Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Cattle
Citrate (si)-Synthase / metabolism*
Heart Atria / enzymology
Heart Ventricles / enzymology
Isoenzymes
L-Lactate Dehydrogenase / metabolism*
Myocardium / enzymology*
Oxo-Acid-Lyases / metabolism*
Papillary Muscles / enzymology
Chemical
Reg. No./Substance:
0/Isoenzymes; 56-65-5/Adenosine Triphosphate; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.3.3.1/Citrate (si)-Synthase; EC 4.1.3.-/Oxo-Acid-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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