Document Detail

Regional distribution of citrate synthase and lactate dehydrogenase isoenzymes in the bovine heart.
MedLine Citation:
PMID:  2750536     Owner:  NLM     Status:  MEDLINE    
Gradients of oxidative and glycolytic enzyme activities in the heart were studied by comparing samples taken from 10 locations from each of six bull hearts, within 30 min after slaughter. Citrate synthase (CS) was used as a marker of the oxidative potential and the lactate dehydrogenase (LD) subunits II and M as markers of aerobic glycolytic and anaerobic glycolytic potential respectively. CS activity in the ventricular tissue was greater than that of the right atrium, and no difference was found between the right and left ventricles. The left ventricular free wall had higher CS activity at the base than at the apex of the heart. Both the H and M subunit activities of LD increased in the following order: right atrium, right ventricle, ventricular septum, left ventricle. The left ventricular free wall showed higher H and M subunit activities at the base than at the apex. Within the left ventricular wall at the base, subendocardium had higher H and M subunit activities than subepicardium. The M subunit constituted the highest fraction of LD in the subendocardium and in the papillary muscle of the left ventricle. In conclusion, this study suggests that there are metabolic differences along both the radial and the longitudinal axes of the left ventricle and across the ventricular septum. These differences indicate that the greatest cellular stress, both aerobic glycolytic and anaerobic glycolytic in nature, occurs within the subendocardium at the base of the left ventricle and in the left ventricular papillary muscle.
C Sylvén; L Lin; A Kallner; F Jansson
Related Documents :
1155906 - Normal left echoventriculography.
2375396 - Biaxial mechanical behavior of excised ventricular epicardium.
3967346 - Relationship between myocardial fiber direction and segment shortening in the midwall o...
7499906 - Can dobutamine echocardiography distinguish necrotic from ischemic myocardium, early af...
21613426 - The toll-like receptor 4-antagonist eritoran reduces murine cardiac hypertrophy.
23615576 - Hbi-3000 prevents secondary sudden cardiac death.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  136     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-15     Completed Date:  1989-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  331-7     Citation Subset:  IM    
Department of Internal Medicine, Huddinge Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphate / metabolism
Citrate (si)-Synthase / metabolism*
Heart Atria / enzymology
Heart Ventricles / enzymology
L-Lactate Dehydrogenase / metabolism*
Myocardium / enzymology*
Oxo-Acid-Lyases / metabolism*
Papillary Muscles / enzymology
Reg. No./Substance:
0/Isoenzymes; 56-65-5/Adenosine Triphosphate; EC Dehydrogenase; EC (si)-Synthase; EC 4.1.3.-/Oxo-Acid-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effects of various gastrins on intracellular free Ca2+ in isolated pig parietal cells.
Next Document:  Shortening velocity, myosin light chain phosphorylation and Ca2+ dependence of force during metaboli...