Document Detail

Regional differences in the recovery of gastric acid secretion after Helicobacter pylori eradication: evaluations with Congo red chromoendoscopy.
MedLine Citation:
PMID:  17055856     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gastric-acid secretion is reduced in Helicobacter pylori-positive fundic atrophic gastritis, but it is restored by the eradication. However, changes in the distribution of acid-secreting mucosa after the eradication remain unknown. Congo red chromoendoscopy is capable of visualizing the acid-secreting fundic mucosa. OBJECTIVE: To evaluate the effect of H pylori eradication on the distribution of acid-secreting mucosa in the fundus by using Congo red chromoendoscopy. DESIGN: An assessment of the distribution of acid-secreting mucosa by the visualized images of Congo red chromoendoscopy and a histologic evaluation of biopsy specimens were performed before and 1 and 7 months after the eradication. The areas of the acid-secreting mucosa in the lesser and greater curvatures of the fundus were evaluated semiquantitatively. PATIENTS: Thirty-seven patients positive for H pylori and with fundic atrophic gastritis. RESULTS: The area of the acid-secreting mucosa increased in 27 cases (73%) by 1 month after eradication, and in 32 cases (86%) by 7 months. This expansion of the acid-secreting mucosa coincided with the improvement of inflammatory changes rather than with that of the mucosal atrophy and was more prominent on the greater curvature than on the lesser curvature. CONCLUSIONS: The acid-secreting mucosa in the fundus expanded in most cases with fundic atrophic gastritis after H pylori eradication, which could be responsible for the increase in acid secretion after the treatment. Regional differences in the recovery of local acid secretion may be associated with site-specific susceptibility to the development of gastric cancer after successful eradication.
Hitoshi Sekine; Katsunori Iijima; Tomoyuki Koike; Yasuhiko Abe; Akira Imatani; Katsuaki Kato; Suichi Ohara; Tooru Shimosegawa
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Publication Detail:
Type:  Journal Article     Date:  2006-09-01
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  64     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  678-85     Citation Subset:  IM    
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
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MeSH Terms
Coloring Agents / diagnostic use*
Congo Red / diagnostic use*
Follow-Up Studies
Gastric Acid / secretion*
Gastric Fundus / microbiology,  pathology,  secretion
Gastric Mucosa / microbiology,  pathology,  secretion
Gastritis, Atrophic / etiology,  metabolism,  pathology
Helicobacter Infections / complications,  diagnosis*,  metabolism*,  microbiology,  pathology
Helicobacter pylori*
Middle Aged
Prospective Studies
Recovery of Function*
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Coloring Agents; 573-58-0/Congo Red
Comment In:
Gastrointest Endosc. 2006 Nov;64(5):686-90   [PMID:  17055857 ]

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