| Regional differences in neostigmine-induced contraction and relaxation of stomach from diabetic guinea pig. | |
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MedLine Citation:
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PMID: 21075692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Delayed gastric emptying and autonomic neuropathy have been documented in patients with diabetes mellitus. Some medications used to treat delayed gastric emptying enhance release of acetylcholine from autonomic neurons to strengthen gastric contractions. Autonomic coordination among gastric regions may be altered in diabetes resulting in poor outcomes in response to prokinetic drugs. Fundus, antrum, and pylorus from STZ or control guinea pigs were treated with neostigmine to mimic release of acetylcholine from autonomic neurons by prokinetic agents. In diabetic animals, neostigmine-induced contractions were weaker in fundus and pylorus but similar in antrum. The muscarinic receptor antagonist 4-DAMP or the nicotinic receptor antagonist hexamethonium reduced neostigmine-induced contractions. Activation of presynaptic muscarinic receptors on nitrergic neurons was impaired in fundus and antrum from diabetic animals. Nerve-stimulated contractions and relaxations, number of nNOS myenteric neurons, and tissue choline content were reduced in fundus from diabetic animals. Despite reduced number of myenteric neurons, tissue choline content was increased in antrum from diabetic animals. Since cholinergic motility of each gastric region was affected differently by diabetes, prokinetic drugs that nondiscriminately enhance acetylcholine release from autonomic neurons may not effectively normalize delayed gastric emptying in patients with diabetes and more selective medications may be warranted. |
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Authors:
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Joseph Cellini; Karyn DiNovo; Jessica Harlow; Kathy J LePard |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-13 |
Journal Detail:
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Title: Autonomic neuroscience : basic & clinical Volume: 160 ISSN: 1872-7484 ISO Abbreviation: Auton Neurosci Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-07 Completed Date: 2011-05-19 Revised Date: 2012-02-27 |
Medline Journal Info:
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Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 69-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Physiology, Chicago College of Osteopathic Medicine, Midwestern University, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System Diseases / physiopathology Diabetes Mellitus, Experimental / complications, physiopathology* Diabetic Neuropathies / physiopathology Gastric Emptying / drug effects, physiology Gastrointestinal Motility / drug effects*, physiology Guinea Pigs Male Muscle Contraction / drug effects*, physiology Muscle Relaxation / drug effects*, physiology Muscle, Smooth / drug effects, physiology Neostigmine / pharmacology Parasympathomimetics / pharmacology Stomach / drug effects*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R15 NS047106/NS/NINDS NIH HHS; R15 NS047106-01A1/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Parasympathomimetics; 59-99-4/Neostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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