Document Detail

Regional differences in lactate concentration in experimental myocardial infarction.
MedLine Citation:
PMID:  1065294     Owner:  NLM     Status:  MEDLINE    
Lacate concentrations were measured in blood from (a) coronary veins within ischaemic myocardium and (b) veins nearer to the coronary vein, for periods of up to 2 1/2 hours after ligation of the left anterior descending artery in dogs. Concentrations at (a) were three to four times higher than at (b), while blood sampled simultaneously from two veins at (a) yielded similar concentrations of lactate. At 2 1/2 hours after ligation the veno-arterial difference of lactate concentration in blood from (a) was about one half of the difference at 15 minutes. Lactate concentration at (a) was approximately twice as great when the area of ischaemic myocardium drained by the vein was large (18 not equal to 1% of heart weight) than when it was small (6 not equal to 1% of heart weight). No close correlation was apparent between the height of epicardial ST-segment elevation and the level of lactate release. These experiments extend previous observations that changes in lactate concentration at a given site may reflect changes in venous dilution, rather than in the rate of production of lactate, and emphasize that caution is necessary in interpretation of changes in concentrations of metabolites in coronary sinus blood after acute myocardial infarction in man.
H J Smith; R M Norris; B N Singh; M K Heng; E A Harris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  6     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
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MeSH Terms
Coronary Vessels*
Lactates / blood*
Myocardial Infarction / blood*,  diagnosis
Time Factors
Reg. No./Substance:

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