Document Detail

Regional differences in the effect of oestrogen on vascular tone in isolated rabbit arteries.
MedLine Citation:
PMID:  12420796     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to assess how oestrogen acutely affects the tone of isolated artery segments from different vascular beds in rabbit. Cumulative concentrations of 17beta-oestradiol were added to ring segments of thoracic aorta, pulmonary artery, ear artery and coronary arteries from adult male rabbits. Coronary arteries precontracted with potassium or the thromboxane agonist, U46619, relaxed to oestrogen (10(-7) to 10(-4) M), whereas oestrogen (10(-8) to 10(-4) M) only caused additional contraction in segments of thoracic aorta and pulmonary artery precontracted with phenylephrine. In the thoracic aorta both the phospholipase C inhibitor NCDC (10(-4) M) and the cyclooxygenase inhibitor indomethacin (10(-5) M) almost completely blocked the contractile effect of oestrogen. In segments of the ear artery, oestrogen caused relaxation only at higher concentrations of oestrogen (10(-5) to 10(-4) M). In conclusion, oestrogen may cause both relaxation and vasoconstriction in different vascular beds, and in the thoracic aorta the contractile effects of oestrogen may be mediated via inositol phosphate-dependent pathways and release of prostaglandins.
Ole Saetrum Opgaard; Sue P Duckles; Diana N Krause
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  91     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2003-03-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Department of Pharmacology, College of Medicine, University of California, Irvine 92697-4625, USA.
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MeSH Terms
Aorta, Thoracic / drug effects
Coronary Vessels / drug effects
Drug Interactions
Estrogens / pharmacology*
Muscle, Smooth, Vascular / drug effects*
Pulmonary Artery / drug effects
Vasoconstriction / drug effects
Vasoconstrictor Agents / pharmacology*
Vasodilator Agents / pharmacology*
Grant Support
Reg. No./Substance:
0/Estrogens; 0/Vasoconstrictor Agents; 0/Vasodilator Agents

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