Document Detail

Regional differences in the distribution of norepinephrine and epinephrine in human cerebral cortex: a neurochemical study using HPLC and electrochemical detection.
MedLine Citation:
PMID:  2725950     Owner:  NLM     Status:  MEDLINE    
We performed neurochemical quantitation of the catecholamines dopamine (DA), norepinephrine (NE) and epinephrine (E) and their major metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in 22 cortical regions of 6 postmortem human brains. Statistical analysis indicated a clear regional difference for NE and E while DA and all the metabolites under study are homogeneously distributed over the cortex. These consistent regional differences suggest the possible role of NE and E as neurotransmitters or neuromodulators in human cerebral cortex.
P Herregodts; Y Michotte; G Ebinger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  98     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-07-10     Completed Date:  1989-07-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Department of Neurology, Vrije Universiteit Brussel, Belgium.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / analysis
Cerebral Cortex / analysis*,  physiology
Chromatography, High Pressure Liquid
Dopamine / analysis*,  physiology
Epinephrine / analysis*,  physiology
Homovanillic Acid / analysis
Methoxyhydroxyphenylglycol / analysis
Middle Aged
Norepinephrine / analysis*,  physiology
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol

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