Document Detail

Regional differences in the control of lipolysis in human adipose tissue.
MedLine Citation:
PMID:  229383     Owner:  NLM     Status:  MEDLINE    
Omental fat cells were 30% smaller than those in subcutaneous regions. In omental fat cells with a mean diameter of 95 mu, the basal cAMP concentration was 50% lower, but the basal rate of glycerol release was three times as rapid as in subcutaneous (epigastric) fat cells of identical size. Added at maximal effective concentration, noradrenaline increased the level of cAMP and the rate of glycerol release more markedly in the omental than in the subcutaneous adipocytes, whereas the response to isopropyl noradrenaline was similar. Before starvation the lipolytic effects of noradrenaline and isopropyl noradrenaline, respectively, were identical in the two regions of subcutaneous adipose tissue investigated (femoral and hypogastric). The findings were well related to the tissue levels of cAMP induced by the two agents. During starvation noradrenaline and isopropyl noradrenaline increased the cAMP level and the rate of lipolysis in fat cells obtained from the hypogastric region, whereas noradrenaline decreased these parameters in femoral adipocytes. Starvation was associated with a more prominent inhibitory effect of phenylephrine on basal and isopropyl-noradrenaline-induced lipolysis in femoral than in hypogastric adipose tissue. In conclusion, differences exist between different regions of adipose tissue in their lipolytic responsiveness to noradrenaline, which seems related to the balance between alpha- and beta-adrenergic receptor response.
J Ostman; P Arner; P Engfeldt; L Kager
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  28     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1198-205     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / cytology,  metabolism*
Cyclic AMP / metabolism
Fatty Acids, Nonesterified / metabolism
Glycerol / biosynthesis
Isoproterenol / pharmacology
Lipolysis / drug effects*
Middle Aged
Norepinephrine / pharmacology
Phentolamine / pharmacology
Starvation / metabolism
Theophylline / pharmacology
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 56-81-5/Glycerol; 58-55-9/Theophylline; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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