| Regional differences in cerebral vasomotor control by nitric oxide. | |
| | |
MedLine Citation:
|
PMID: 8535859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Regional differences in the role of nitric oxide in cerebral vasomotor control were investigated with a nitric oxide synthesis inhibitor, NG-monomethyl-L-arginine, or a precursor of nitric oxide, L-arginine using both dog cerebral angiography for the larger artery study and rat isolated arterioles for the microcirculation study. NG-monomethyl-L-arginine (10 mumol) constricted the dog cerebral arteries, by 15.6%, 17.5%, and 27.3% in the middle cerebral, anterior cerebral, and basilar arteries, respectively. The greater constriction of the basilar artery did not reach statistical significance. However, L-arginine (100 mumol) produced significantly greater dilation of basilar arteries than the middle cerebral or anterior cerebral (31.3% vs. 16.7% or 13.1%). NG-monomethyl-L-arginine at 10(-3) M constricted rat arterioles originating from basilar arteries significantly more than the middle cerebral arteries (23% vs. 14%). L-arginine at 10(-3) M dilated rat arterioles from basilar arteries significantly more than from the middle cerebral artery (24 vs. 11%). These findings suggest that the roles of nitric oxide in vasomotor control differs by region in the brain, and it may be greater in vessels of the posterior than of the anterior circulation. |
| | |
Authors:
|
Y Kajita; M Takayasu; Y Suzuki; M Shibuya; M Mori; H Oyama; K Sugita; H Hidaka |
Related Documents
:
|
3750189 - Radiologic evaluation of extracranial to sylvian middle cerebral artery bypass. 430149 - Superficial temporal artery to middle cerebral artery anastomosis. intraoperative evalu... 17456649 - Cerebral oxygen desaturation after cardiopulmonary bypass in a patient with raynaud's p... 3393069 - An interposed superficial temporal artery graft bypass for anterior cerebral artery isc... 19401159 - Nuclear contrast angiography: a simple method for morphological characterization of cer... 6400429 - Effects of barbiturates, phencyclidine, ketamine and analogs on cerebral circulation an... 11927999 - Corona mortis: incidence and location. 8489859 - In vivo detection of endothelium dependent and independent pulmonary artery relaxation ... 16115479 - Evidence of vascular dysfunction in young patients with successfully repaired coarctati... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Brain research bulletin Volume: 38 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1995 |
Date Detail:
|
Created Date: 1996-02-08 Completed Date: 1996-02-08 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 365-9 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Nagoya University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arginine / analogs & derivatives, pharmacology Arterioles / drug effects, physiology Cerebral Arteries / drug effects, physiology Cerebrovascular Circulation / drug effects, physiology* Dogs Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology Female Hydrogen-Ion Concentration Male Microcirculation / drug effects, physiology Nitric Oxide / physiology* Nitric Oxide Synthase / antagonists & inhibitors Rats omega-N-Methylarginine |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of chronic naloxone administration on vacuous chewing movements and catalepsy in rats treate...
Next Document: 192IGG-saporin-induced selective lesion of cholinergic basal forebrain system: neurochemical effects...