Document Detail

Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment.
MedLine Citation:
PMID:  20545902     Owner:  NLM     Status:  In-Process    
We analyzed regional differences in human leukocyte antigen (HLA)-A, -B, and -DR antigen and haplotype frequencies based on a sample of approximately 320,000 German donors in order to identify regions that are especially suited for ongoing stem cell donor recruitment. Geographic partitioning was carried out by postal code regions. Analysis of genetic distances suggests the existence of three regional clusters in South (regions 6-9), East (0-1), and Northwest (2-5) Germany. The southern cluster shows most favorable characteristics with respect to haplotypic and phenotypic diversity and the occurrence of rare HLA antigens. The opposite behavior is shown by regions 2-4 of the northwestern cluster. As a result of lower HLA diversity, completeness of a regional donor file in region 4 with 100,000 donors would be higher than that of a file in region 7 with 170,000 donors. This fact shows the relevance of regional HLA differences for practical donor registry planning. Results such as those presented in this work can be used to diminish the problem of decreasing marginal benefit of donor recruitment, as more than 13 million donors are registered worldwide today.
A H Schmidt; U V Solloch; D Baier; A Stahr; R Wassmuth; G Ehninger; C Rutt
Publication Detail:
Type:  Journal Article     Date:  2010-08-19
Journal Detail:
Title:  Tissue antigens     Volume:  76     ISSN:  1399-0039     ISO Abbreviation:  Tissue Antigens     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  362-79     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
DKMS German Bone Marrow Donor Center, Tübingen, Germany.
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