Document Detail


Regional differences between various axial segments of the avian neural crest regarding the formation of enteric ganglia.
MedLine Citation:
PMID:  7685298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vagal neural crest adjacent to somites 1-7 gives rise to the enteric ganglia along the entire digestive tract. It is generally assumed that formation of enteric ganglia in preumbilical gut is independent of the axial segment from which the neural crest originates. In post-umbilical gut, however, there is evidence that the axial segment of origin of the neural crest might be relevant to neural differentiation. In this part of the gut, we previously identified a subpopulation of HNK-1-immunoreactive cells within the enteric mesenchyme. This immunoreactivity disappeared upon formation of the enteric nervous system. We studied the interaction between various axial segments of quail neural crest and the microenvironment in a neural chicken hindgut using chorioallantoic membrane cocultures. We found that neural crest cells from various axial segments could migrate into the gut and home to the correct sites. However, whereas vagal neural crest cells differentiated into enteric neurons, neural crest cells from truncal segments mainly differentiated into melanocytes. The HNK-1-immunoreactivity within the enteric mesenchyme only disappeared when neural crest cell colonization was followed by differentiation into enteric neurons and subsequent formation of enteric ganglia. To determine whether differentiation of neural crest cells in chorioallantoic membrane cocultures was influenced by the prolonged presence of the neural tube and notochord, we developed a new coculture system, using neural crest cells cultured in vitro.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M J Peters-van der Sanden; T M Luider; A W van der Kamp; D Tibboel; C Meijers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  53     ISSN:  0301-4681     ISO Abbreviation:  Differentiation     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-13     Completed Date:  1993-07-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
Affiliation:
Department of Pediatric Surgery, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD57
Antigens, Differentiation / analysis
Cell Differentiation*
Chick Embryo
Coturnix / embryology
Ganglia / embryology,  physiology*
Intestines / embryology,  innervation*
Neural Crest / physiology*
Chemical
Reg. No./Substance:
0/Antigens, CD57; 0/Antigens, Differentiation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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