Document Detail

Regional diastolic contour abnormalities during contrast stress echocardiography: improved detection of coronary artery disease.
MedLine Citation:
PMID:  18926388     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Use of contrast improves detection of systolic regional wall motion abnormalities (RWMAs) during stress echocardiography. We evaluated regional diastolic contour abnormalities (RDCAs) that were associated with coronary artery disease (CAD). METHODS: From August of 2003 to September of 2004, we evaluated 89 patients who underwent contrast stress echocardiography (CSE) and coronary angiography within a 3-month period ("invasive" group) and 17 patients with lower CAD risk who underwent CSE only ("reference" group). RESULTS: RDCAs were present in 73 patients in the invasive group and were associated with higher Framingham risk scores (relative risk, 3.6; 95% confidence interval, 1.9-6.6). RDCAs were present in 1 patient in the reference group. When combined with RWMA, RDCA improved sensitivity of CSE from 78% to 97% and specificity from 26% to 59% (diagnostic threshold for CAD was 70% stenosis). CONCLUSION: RDCAs were a novel observation associated with higher CAD risk and improved the diagnostic accuracy of CSE.
Sonja Cukon-Buttignoni; Sahar S Abdelmoneim; Jo-Ellen Ehrsam; Marion E Barnes; Mary E Hagen; Lori A Carlson; Sabino Iliceto; Sharon L Mulvagh
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  21     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-17     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1109-15     Citation Subset:  IM    
Division of Cardiovascular Diseases, Rochester, Minnesota, USA.
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MeSH Terms
Contrast Media
Coronary Artery Disease / complications,  ultrasonography*
Echocardiography / methods*
Exercise Test*
Fluorocarbons / diagnostic use*
Image Enhancement / methods*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Ventricular Dysfunction, Left / etiology,  ultrasonography*
Reg. No./Substance:
0/Contrast Media; 0/Definity; 0/Fluorocarbons

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