| Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression. | |
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MedLine Citation:
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PMID: 20832254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to examine the effect of type 2 diabetes with major depression on cortical gray matter using magnetic resonance imaging and cortical pattern matching techniques. We hypothesized that diabetic subjects and depressed diabetic subjects would demonstrate decreased cortical gray matter thickness in prefrontal areas as compared to healthy control subjects. Patients with type 2 diabetes (n=26) and patients with diabetes and major depression (n=26) were compared with healthy controls (n=20). Gray matter thickness across the entire cortex was measured using cortical pattern matching methods. All subjects with diabetes demonstrated decreased cortical gray matter thickness in the left anterior cingulate region. Additionally, depressed diabetic subjects showed significant cortical gray matter decreases in bilateral prefrontal areas compared with healthy controls. Correlations between clinical variables and cortical gray matter thickness revealed a significant negative relationship with cerebrovascular risk factors across all three groups, most consistently in the left dorsomedial prefrontal cortex. A significant positive relationship between performance on attention and executive function tasks and cortical gray matter thickness predominantly in left hemisphere regions was also seen across all subjects. Depression and diabetes are associated with significant cortical gray matter thinning in medial prefrontal areas. |
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Authors:
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Olusola Ajilore; Katherine Narr; Jonah Rosenthal; Daniel Pham; Liberty Hamilton; Kecia Watari; Virginia Elderkin-Thompson; Christine Darwin; Arthur Toga; Anand Kumar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: Psychiatry research Volume: 184 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2011-03-23 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 63-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Psychiatry, University of Illinois-Chicago, Chicago, IL, USA. oajilore@psych.uic.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Attention Brain Mapping Cerebral Cortex / pathology*, physiopathology Chi-Square Distribution Depressive Disorder, Major / pathology*, physiopathology Diabetes Mellitus, Type 2 / pathology*, physiopathology Executive Function Female Functional Laterality Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Nerve Fibers, Unmyelinated / pathology* Neuropsychological Tests |
| Grant Support | |
ID/Acronym/Agency:
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MH-02043/MH/NIMH NIH HHS; MH-55115/MH/NIMH NIH HHS; MH-61567/MH/NIMH NIH HHS; R01 MH063764-07/MH/NIMH NIH HHS; R01-MH-63674/MH/NIMH NIH HHS |
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