| Regional coronary hemodynamic effects of diltiazem in man. | |
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MedLine Citation:
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PMID: 3414493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the changes in regional coronary hemodynamics induced by diltiazem, 0.25 mg/kg intravenously, in nine patients with 75% to 90% diameter stenosis of the left anterior descending coronary artery (LAD) (group 1) and in 10 patients with 100% occlusion of the LAD and collaterals to the distal LAD (group 2). Although diltiazem induced similar changes in systemic hemodynamics in the two groups, a decrease in anterior coronary vascular resistance (ACVR) and an increase in great cardiac vein flow (GCVF) were observed after administration of diltiazem in all patients in group 1 but in only 6 of 10 patients in group 2 (subgroup 2B). ACVR increased and GCVF decreased after administration of diltiazem in 4 of 10 patients in group 2 (subgroup 2A). Clinico-angiographic characteristics, origin of collaterals, and diltiazem-induced changes in systemic hemodynamics were similar in subgroups 2A and 2B. Thus diltiazem increases coronary flow distal to a stenotic coronary artery but can decrease regional coronary flow and increase regional coronary resistance in a minority of patients with an occluded coronary artery supplied by collaterals, probably through a steal mechanism. |
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Authors:
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C Vigorito; A Giordano; L De Caprio; V Canonico; P Ferraro; N Farese; P Silvestri; M Catanzaro; F Rengo |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 116 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-10-13 Completed Date: 1988-10-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 799-805 Citation Subset: AIM; IM |
Affiliation:
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I Cattedra di Medicina Interna, Istituto di Medicina Interna, University of Naples, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Circulation
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drug effects* Coronary Disease / classification, physiopathology* Diltiazem / administration & dosage, pharmacology* Female Hemodynamics / drug effects Humans Injections, Intravenous Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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42399-41-7/Diltiazem |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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