Document Detail

Regional coronary haemodynamic effects of two inhibitors of nitric oxide synthesis in anaesthetized, open-chest dogs.
MedLine Citation:
PMID:  1786519     Owner:  NLM     Status:  MEDLINE    
1. The role of endothelial nitric oxide synthesis from L-arginine in the regulation of coronary vascular tone and myocardial tissue perfusion was evaluated in anaesthetized, open-chest dogs. Coronary blood flow was measured with an electromagnetic flow probe placed around the left circumflex coronary artery. Coronary vascular resistance was calculated from mean arterial blood pressure and mean coronary blood flow, whereas regional myocardial tissue flow was determined by use of the radioactive microspheres technique. 2. NG-monomethyl L-arginine (L-NMMA) and NG-nitro-L-arginine methyl ester (L-NAME), administered directly into the left circumflex artery, induced a small increase in arterial blood pressure and an increase in coronary vascular resistance. However, myocardial tissue perfusion, assessed by the microspheres technique (whether subendocardial, subepicardial, or transmural), was unaffected by L-NMMA or L-NAME. 3. Acetylcholine, administered intracoronarily, induced an increase in left circumflex coronary blood flow and a decrease in coronary vascular resistance, without affecting systemic haemodynamics. This coronary vasodilator effect of acetylcholine was markedly inhibited by L-NMMA and L-NAME, the latter being a more potent antagonist than the former. 4. These results indicate that the endothelial L-arginine pathway is largely responsible for the coronary vasodilator effect of acetylcholine. However, although basal release of nitric oxide from L-arginine apparently contributes to the regulation of resting coronary vascular tone, blockade of this pathway does not affect myocardial tissue perfusion, possibly because of compensatory mechanisms occurring at the level of small arterioles and/or capillaries.
V Richard; A Berdeaux; C D la Rochelle; J F Giudicelli
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  104     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Laboratoire de Pharmacologie, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France.
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MeSH Terms
Acetylcholine / pharmacology
Arginine / analogs & derivatives*,  pharmacology
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects
Muscle Tonus / drug effects
NG-Nitroarginine Methyl Ester
Nitric Oxide / metabolism*
Vascular Resistance / drug effects
Reg. No./Substance:
10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-84-3/Acetylcholine; 74-79-3/Arginine

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