| Regional changes in myocyte size during the reversal of thyroid-induced cardiac hypertrophy. | |
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MedLine Citation:
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PMID: 2974888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regional changes in cardiac myocyte size resulting from thyroid treatment, and the subsequent reversal of hypertrophy following removal of the thyrotoxic stimulus, were examined. Isolated myocytes were prepared from weight-matched controls and rats treated with desiccated thyroid hormone for 10 weeks. Cells were collected from the right and left ventricles. Cell volume was determined with a Coulter Channelyzer system. Cell length was measured directly using a phase microscope. Myocyte cross-sectional area was calculated from cell volume/length. After 10 weeks thyroid treatment, cell volume was increased in all regions, especially the right ventricle and the epimyocardium of the left ventricle (P less than 0.01). Although cell length was increased in all regions (N.S.), most of the myocyte hypertrophy was due to an increase in cross-sectional area, especially in the right ventricle (P less than 0.01) and epimyocardium of the left ventricle (N.S.). By 2 weeks post-treatment, a substantial regression of myocyte hypertrophy had occurred. However, heart weight was still significantly larger than control (P less than 0.001), due to an incomplete regression of myocyte volume. This study indicates that thyroid hormones stimulate myocyte hypertrophy by increasing both cross-sectional area and cell length. The response is more pronounced in right ventricles than in left ventricles. Within the left ventricle, epimyocardial cells enlarge the most. At 2 weeks post-treatment, cardiac hypertrophy is still present and myocytes have not completely returned to a normal size. |
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Authors:
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S E Campbell; A M Gerdes |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 20 ISSN: 0022-2828 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 1988 May |
Date Detail:
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Created Date: 1989-02-21 Completed Date: 1989-02-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 379-87 Citation Subset: IM |
Affiliation:
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Department of Anatomy, University of South Florida, Tampa, FL 33612. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Cardiomegaly / etiology, pathology, physiopathology* Female Heart Rate Hyperthyroidism / physiopathology Myocardium / pathology* Organ Size Rats Rats, Inbred Strains Thyroid Gland / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL30696/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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