Document Detail

Regional changes in monoamines and metabolites following defensive aggression in the rat.
MedLine Citation:
PMID:  6202379     Owner:  NLM     Status:  MEDLINE    
Pharmacological studies have demonstrated that shock-induced defensive fighting is modulated by manipulations of the serotonergic, noradrenergic and dopaminergic neurotransmitter systems. In the present study, regional changes in 5- hydroxytryptamine , norepinephrine, dopamine and their metabolites 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylethylene glycol and 3,4-dihydroxyphenylacetic acid were measured following shock-induced fighting using high performance liquid chromatography coupled with electrochemical detection. Fighting produced reductions in the serotonergic, noradrenergic and dopaminergic systems and elevations in the noradrenergic and dopaminergic systems within the brain stem, hypothalamus, hippocampus, caudate and amygdala relative to shocked or non-shocked controls. These data demonstrate that the activities of these neurotransmitters are involved in defensive aggression in rats. The changes in catecholamines may indicate adaptive responses to stress, while the changes in serotonin may indicate a permissive function for serotonin depletion in defensive fighting.
K M Kantak; L R Hegstrand; B Eichelman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  12     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-07-19     Completed Date:  1984-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / analysis
Aggression / physiology*
Biogenic Amines / analysis*
Brain Chemistry
Dopamine / analysis
Hydroxyindoleacetic Acid / analysis
Methoxyhydroxyphenylglycol / analysis
Norepinephrine / analysis
Serotonin / analysis
Grant Support
Reg. No./Substance:
0/Biogenic Amines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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