Document Detail

Regional V/Q changes in asthmatics after exercise.
MedLine Citation:
PMID:  3462018     Owner:  NLM     Status:  MEDLINE    
The immediate changes in regional ventilation and pulmonary blood flow were studied in fifteen adults with perennial asthma and in two control persons, who were challenged by moderate exercise on a treadmill or bicycle ergometer. Ventilation was studied before and immediately after the exercise, and again about five min after stopping the provocation. Peak expiratory flow was checked at regular intervals. Five min after cessation of the exercise ventilation had become patchy and irregular, but the pulmonary blood flow distribution remained "normal", i.e. as seen in the resting state. The ventilatory defects could be prevented by pretreatment with terbutaline or eliminated by terbutaline treatment after development of signs and symptoms. From repeat studies it can be concluded that the development of regional ventilatory defects after EIA do not follow a stereotypic course nor are defects similar to those provoked by histamine or allergens.
T Munkner; A Bundgaard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of respiratory diseases. Supplement     Volume:  143     ISSN:  0106-4347     ISO Abbreviation:  Eur J Respir Dis Suppl     Publication Date:  1986  
Date Detail:
Created Date:  1986-10-16     Completed Date:  1986-10-16     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  8010618     Medline TA:  Eur J Respir Dis Suppl     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  62-6     Citation Subset:  IM    
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MeSH Terms
Asthma / physiopathology*
Asthma, Exercise-Induced / physiopathology*
Lung / radionuclide imaging
Middle Aged
Peak Expiratory Flow Rate
Ventilation-Perfusion Ratio*

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