| Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans. | |
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MedLine Citation:
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PMID: 18037671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the distribution of the metabolism in the brain (P<0.0001 analysis of variance). Compared with inhalation of O2 30% in N2, N2O 50% inhalation increased the metabolism in the basal ganglia [14 (17)%, P<0.05] and thalamus [22 (23) %, P<0.05]. There was a prolonged metabolic effect of N2O inhalation seen on a succeeding PET scan with oxygen-enriched air (P<0.0001) performed 1 h after the N2O administration. CONCLUSIONS: Inhalation of N2O 50% did not change global CMR(glu), but the metabolism increased in central brain structures, an effect that was still present 1 h after discontinuation of N2O. |
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Authors:
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P Reinstrup; E Ryding; T Ohlsson; A Sandell; K Erlandsson; K Ljunggren; L G Salford; S Strand; T Uski |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-23 |
Journal Detail:
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Title: British journal of anaesthesia Volume: 100 ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-11 Completed Date: 2008-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 66-71 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care, University Hospital, S22185 Lund, Sweden. peter.reinstrup@med.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Inhalation / pharmacology* Brain / drug effects*, metabolism, radionuclide imaging Cerebrovascular Circulation / drug effects Fluorodeoxyglucose F18 / diagnostic use Humans Male Nitrous Oxide / pharmacology* Positron-Emission Tomography Radiopharmaceuticals / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Radiopharmaceuticals; 10024-97-2/Nitrous Oxide; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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