Document Detail


Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans.
MedLine Citation:
PMID:  18037671     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the distribution of the metabolism in the brain (P<0.0001 analysis of variance). Compared with inhalation of O2 30% in N2, N2O 50% inhalation increased the metabolism in the basal ganglia [14 (17)%, P<0.05] and thalamus [22 (23) %, P<0.05]. There was a prolonged metabolic effect of N2O inhalation seen on a succeeding PET scan with oxygen-enriched air (P<0.0001) performed 1 h after the N2O administration. CONCLUSIONS: Inhalation of N2O 50% did not change global CMR(glu), but the metabolism increased in central brain structures, an effect that was still present 1 h after discontinuation of N2O.
Authors:
P Reinstrup; E Ryding; T Ohlsson; A Sandell; K Erlandsson; K Ljunggren; L G Salford; S Strand; T Uski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-23
Journal Detail:
Title:  British journal of anaesthesia     Volume:  100     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-11     Completed Date:  2008-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-71     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Intensive Care, University Hospital, S22185 Lund, Sweden. peter.reinstrup@med.lu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthetics, Inhalation / pharmacology*
Brain / drug effects*,  metabolism,  radionuclide imaging
Cerebrovascular Circulation / drug effects
Fluorodeoxyglucose F18 / diagnostic use
Humans
Male
Nitrous Oxide / pharmacology*
Positron-Emission Tomography
Radiopharmaceuticals / diagnostic use
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Radiopharmaceuticals; 10024-97-2/Nitrous Oxide; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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