Document Detail


Regional cerebral glucose metabolism of newborn infants measured by positron emission tomography.
MedLine Citation:
PMID:  6602073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The new diagnostic technique, positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose (18FDG), was used to measure regional cerebral glucose metabolism in five newborn infants with demonstrated structural abnormalities of the brain. 18FDG was synthesized, diluted in normal saline and injected intravenously. After one hour, tomographic slices of the brain were obtained, the level of the slices being defined relative to the cerebral ventricles. Glucose metabolism of grey- and white-matter structures in the brain could be differentiated clearly. Decreased glucose metabolism was identified in regions of the brain shown by computerized axial tomography to be structurally abnormal. Positron emission tomography is a promising new diagnostic tool for the study of newborn infants with suspected abnormalities of brain function.
Authors:
L W Doyle; C Nahmias; G Firnau; D B Kenyon; E S Garnett; J C Sinclair
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  25     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / metabolism*,  radiography,  radionuclide imaging
Female
Glucose / metabolism*
Humans
Infant
Infant, Newborn
Male
Tissue Distribution
Tomography, Emission-Computed*
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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