Document Detail


Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep.
MedLine Citation:
PMID:  15365136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epileptic syndromes with continuous spikes and waves during sleep (CSWS) represent a wide spectrum of epileptic conditions associated with cognitive dysfunctions that have the EEG pattern of CSWS as a common feature. Reported are the results of voxel-based analyses of brain glucose metabolism performed in a group of 18 children with CSWS. METHODS: Voxel-based analyses of cerebral glucose metabolism were performed using statistical parametric mapping (SPM). First, each patient was compared with a control group and the influence of age, epileptic activity, and corticosteroid treatment on metabolic abnormalities was studied. Also, disease-related changes in the contribution of a brain area to the level of metabolic activity in another brain area were investigated using pathophysiologic interactions in groups of patients compared with the control group. RESULTS: Individual SPM analyses identified three metabolic patterns: association of hypermetabolic and hypometabolic areas, hypometabolic areas only, and normal pattern. Age and intensity of awake interictal spiking did not significantly differ in patients showing focal hypermetabolism compared with the other ones. Treatment with corticosteroids was associated with absence of focal hypermetabolism. In the group of patients with hypermetabolic areas, analyses of pathophysiologic interactions showed disease-related altered functional connectivity between the parietal and frontal cortices. CONCLUSIONS: Cerebral metabolic patterns are heterogeneous among patients with CSWS. This metabolic heterogeneity could be related to the use of corticosteroid treatment before PET. The parietofrontal altered connectivity observed in patients with hypermetabolism is interpreted as a phenomenon of remote inhibition of the frontal lobes induced by highly epileptogenic and hypermetabolic posterior cortex.
Authors:
X De Tiège; S Goldman; S Laureys; D Verheulpen; C Chiron; C Wetzburger; P Paquier; D Chaigne; N Poznanski; I Jambaqué; E Hirsch; O Dulac; P Van Bogaert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  63     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2005-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  853-7     Citation Subset:  AIM; IM    
Affiliation:
PET/Biomedical Cyclotron Unit, ULB-Hôpital Erasme, 808 route de Lennik, 1070 Brussels, Belgium. xdetiege@ulb.ac.be
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MeSH Terms
Descriptor/Qualifier:
Brain / metabolism*,  radionuclide imaging
Child
Child, Preschool
Electroencephalography*
Epilepsy / metabolism*,  physiopathology,  radionuclide imaging
Female
Fluorodeoxyglucose F18 / diagnostic use
Frontal Lobe / metabolism,  physiopathology,  radionuclide imaging
Glucose / metabolism*
Humans
Male
Organ Specificity
Positron-Emission Tomography
Radiopharmaceuticals / diagnostic use
Retrospective Studies
Sleep Disorders, Intrinsic / metabolism*,  physiopathology,  radionuclide imaging
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

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