Document Detail

Regional cerebral distribution of [Tc-99m] hexylmethylpropylene amineoxine in patients with progressive aphasia.
MedLine Citation:
PMID:  10918743     Owner:  NLM     Status:  MEDLINE    
Progressive aphasia is a prominent clinical feature of several neurodegenerative disorders. This study used hexylmethylpropylene amineoxine (HMPAO) single photon emission computed tomography (SPECT) to estimate blood flow in areas of the brain that mediate language in patients with progressive aphasia and matched control subjects. The patient population consisted of four men and 12 women with a mean +/- SD age of 69.1 +/- 7.6. Of these, eight were classified as having a nonfluent form of aphasia, whereas the other eight had a fluent form. The patients were compared to 16 healthy volunteers who were studied with an identical protocol. The SPECT images of the brain were acquired with 740 MBq (20 mCi) of Tc-99m-labeled HMPAO on a triple-headed gamma camera equipped with fan beam collimators. The images were analyzed with a set of standardized templates. Mean counts per pixel in 33 regions of interest were compared to the mean counts in the whole supratentorial brain. A laterality index was determined for homotopic regions using the equation 100 x (R - L)/(1/2 x (R - L)). Patients with progressive aphasia had several regions of significantly decreased HMPAO uptake in the left cortex when compared to the homotopic regions on the right. The most prominent deficit in the nonfluent group, as determined by the laterality index, were found in the left dorsolateral prefrontal region (p < 0.05), whereas the most prominent deficits in the group with fluent aphasia were found in the left temporal and parietal language centers (p < 0.05). The left subcortical nuclei were differentially affected, particularly in patients with nonfluent aphasia. The HMPAO SPECT indicates that multiple regions of the left hemisphere are dysfunctional in patients with progressive aphasia. The pattern of perfusion deficits in patients with fluent aphasia appears to be distinct from the pattern in patients with nonfluent aphasia.
A B Newberg; P D Mozley; A H Sadek; M Grossman; A Alavi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  10     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-19     Completed Date:  2000-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Division of Nuclear Medicine, University of Pennsylvania Medical Center, Philadelphia, USA.
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MeSH Terms
Alzheimer Disease / radionuclide imaging
Aphasia, Broca / radionuclide imaging*
Aphasia, Wernicke / radionuclide imaging*
Brain Mapping
Cerebral Cortex / blood supply,  radionuclide imaging*
Dominance, Cerebral / physiology
Follow-Up Studies
Middle Aged
Regional Blood Flow / physiology
Technetium Tc 99m Exametazime / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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