Document Detail


Regional cerebral blood flow utilizing the gamma camera and xenon inhalation: reproducibility and clinical applications.
MedLine Citation:
PMID:  4089919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A modified collimator and standard gamma camera have been used to measure regional cerebral blood flow following inhalation of radioactive xenon. The collimator and a simplified analysis technique enables excellent statistical accuracy to be achieved with acceptable precision in the measurement of grey matter blood flow. The validity of the analysis was supported by computer modelling and patient measurements. Sixty-one patients with subarachnoid haemorrhage, cerebrovascular disease or dementia were retested to determine the reproducibility of our method. The measured coefficient of variation was 6.5%. Of forty-six patients who had a proven subarachnoid haemorrhage, 15 subsequently developed cerebral ischaemia. These showed a CBF of 42 +/- 6 ml X minute-1 X 100 g brain-1 compared with 49 +/- 11 ml X minute-1 X 100 g brain-1 for the remainder. There is evidence that decreasing blood flow and low initial flow correlate with the subsequent onset of cerebral ischaemia.
Authors:
R A Fox; N W Knuckey; R F Fleay; B A Stokes; A Van der Schaaf; I Surveyor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  16     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-02-21     Completed Date:  1986-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1010-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Adult
Blood Flow Velocity
Cerebrovascular Circulation*
Cerebrovascular Disorders / physiopathology,  radionuclide imaging
Dementia / physiopathology
Female
Humans
Ischemic Attack, Transient / physiopathology,  radionuclide imaging
Male
Middle Aged
Subarachnoid Hemorrhage / physiopathology,  radionuclide imaging
Xenon Radioisotopes / administration & dosage,  diagnostic use*
Chemical
Reg. No./Substance:
0/Xenon Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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