Document Detail


Regional cerebral blood flow (rCBF) in migraine during the interictal period: different rCBF patterns in patients with and without aura.
MedLine Citation:
PMID:  8734767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate the rCBF (133Xe clearance method) in migrainous patients free from attack. Fifty patients suffering from migraine without aura (group M) and 20 suffering from migraine with aura (group MA) (age range 20-50 years) were submitted to 32 channel rCBF mapping during the interictal period. The rCBF data of patients were compared with those obtained from 60 healthy control subjects (group C) and 21 patients suffering from tension-type headache (group TH). The mean (average of all channels) rCBF values were: group M = 70.5 +/- 13.7 ml/100g/min; group MA = 56.6 +/- 11.4 ml/100g/min; group C = 62.3 +/- 8.3 ml/100g/min; group TH = 62.1 +/- 8.4 ml/100g/min (F = 11.93; p < 0.001). As expected, patients belonging to group TH had a normal rCBF. The mean rCBF of group M was significantly higher than that of groups C and TH, while in group MA it was significantly lower than in groups C and TH. Group M showed a diffuse hyperemia, while group MA showed rCBF values significantly lower than normal in posterior regions, according to aura. Our results suggest that: (a) the rCBF pattern in migrainous patients is different from that in both controls and TH patients, even during the interictal period; (b) patients suffering from migraine with and without aura are two distinct subpopulations with opposite rCBF deviations.
Authors:
E Facco; M Munari; F Baratto; A U Behr; A Dal Palù; S Cesaro; M Giacomini; G Giron
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  16     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-14     Completed Date:  1996-11-14     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  161-8     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Intensive Care, University of Padua, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cerebrovascular Circulation / physiology*
Electroencephalography
Female
Humans
Male
Middle Aged
Migraine Disorders / physiopathology*
Prospective Studies
Xenon Radioisotopes / diagnostic use
Chemical
Reg. No./Substance:
0/Xenon Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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