Document Detail

Regional cerebral blood flow and oxygen utilization in superficial temporal-middle cerebral artery anastomosis patients: an exploratory definition of clinical problems.
MedLine Citation:
PMID:  374689     Owner:  NLM     Status:  MEDLINE    
Regional cerebral blood flow (rCBF) and regional cerebral oxygen utilization (rCMRO2) were measured before and after surgery in nine patients undergoing a superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis to bypass cerebrovascular lesions not amenable to extracranial operative procedures. The objective of these studies was to determine whether measurements of this type could provide objective criteria for surgery as well as assess the effect of surgery. The preliminary data, although limited, suggest that measurements of regional cerebral hemodynamics and metabolism in these patients before and after surgery provide valuable data upon which to develop criteria and assess results. For example, 1) a significant depression of rCBF and rCMRO2 in patients in whom a major cerebral infarction has not occurred, or 2) relative preservation of rCMRO2 despite depressed rCBF seem to be favorable indications for establishing a functioning STA-MCA anastomosis. In such patients, STA-MCA anastomosis can be followed by a return of rCBJ and rCMRO2 to virtually normal levels. Relatively normal rCBF and rCMRO2 in the presence of an occluded internal carotid artery in asymptomatic patients indicates satisfactory collateral circulation and is probably a contraindication to surgery.
R L Grubb; R A Ratcheson; M E Raichle; A B Kliefoth; M H Gado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  50     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-07-28     Completed Date:  1979-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-41     Citation Subset:  AIM; IM    
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MeSH Terms
Arterial Occlusive Diseases / physiopathology,  surgery
Brain / metabolism*
Carotid Artery Diseases / diagnosis,  physiopathology,  surgery*
Cerebral Arterial Diseases / diagnosis,  physiopathology,  surgery*
Cerebral Arteries / surgery*
Cerebrovascular Circulation*
Cerebrovascular Disorders / diagnosis,  physiopathology,  surgery*
Collateral Circulation
Ischemic Attack, Transient / diagnosis,  physiopathology,  surgery*
Middle Aged
Oxygen Consumption
Oxygen Radioisotopes
Radioisotope Dilution Technique
Regression Analysis
Temporal Arteries / surgery*
Reg. No./Substance:
0/Oxygen Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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