Document Detail


Regional cerebral blood flow in mood disorders: IV. Comparison of mania and depression.
MedLine Citation:
PMID:  7568564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cortical regional cerebral blood flow (rCBF) was assessed in minimally medicated, relatively young adults in episodes of either acute mania (n = 11) or major depression (n = 11) and in matched normal control subjects (n = 11), using the 133xenon inhalation method, under eyes-closed, resting conditions. The three groups were equivalent in global CBF. Both patient groups showed significant reductions of rCBF in anterior cortical areas and reduction of the normal anteroposterior gradient. In addition, there was evidence of abnormal, albeit similar, patterns of flow lateralization on a regional basis in both clinical groups compared with normal subjects. An exploratory analysis revealed preliminary evidence of rCBF differences between the clinical groups, localized to the inferior frontal cortex. Otherwise, the evidence in this study suggests that young adult manic and depressed patients are predominantly similar in cortical rCBF parameters.
Authors:
E Rubin; H A Sackeim; I Prohovnik; J R Moeller; D B Schnur; S Mukherjee
Related Documents :
21724964 - Valuing the life experience of old adults and change in depressive symptoms: exploring ...
9097214 - Clinical, magnetic resonance imaging and endocrinological differences between delusiona...
18533184 - The glutamatergic system and its relation to the clinical effect of therapeutic-sleep d...
16123774 - Correlations between rcbf and symptoms in two independent cohorts of drug-free patients...
19358784 - A double-blind, placebo-controlled, parallel-group, flexible-dose study of venlafaxine ...
19719334 - Salmeterol/fluticasone propionate: a review of its use in asthma.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  61     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Affiliation:
New York State Psychiatric Institute, NY 10032, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Bipolar Disorder / physiopathology*
Depressive Disorder / physiopathology*
Female
Frontal Lobe / blood supply*,  metabolism,  physiopathology*
Functional Laterality
Humans
Male
Mood Disorders / physiopathology*
Regional Blood Flow*
Xenon / administration & dosage,  diagnostic use,  metabolism
Grant Support
ID/Acronym/Agency:
MH-35636/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
7440-63-3/Xenon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The P50 evoked potential component and mismatch detection in normal volunteers: implications for the...
Next Document:  Gray matter heterotopias in schizophrenia.