Document Detail


Regional cerebral blood flow changes in stroke imaged by Tc-99m HMPAO SPECT with corresponding anatomic image comparison.
MedLine Citation:
PMID:  8293629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral infarction is the result of cerebrovascular insufficiency and itself creates complex changes in cerebral hemodynamics. To allow recognition of patterns of change in regional cerebral blood flow (r-CBF) caused by cerebral infarction, the authors present an atlas of Tc-99m hexamethylpropyleneamine oxime (Tc-99m HMPAO) SPECT brain scan sections for a variety of strokes demonstrating typical vascular territorial involvements and evolution of morphologic and r-CBF change. Sections from MRI or CT are shown with SPECT images of the stroke lesion for comparison of the complementary information provided by regional cerebroperfusion and by morphology. Examples of SPECT during acute, subacute, and chronic stages of stroke are provided. To illustrate the temporal evolution of stroke and accompanying changes in the "stroke penumbra," case examples of acute tissue necrosis, luxury perfusion, ischemia, and diaschisis are presented. Methods for semiquantitative analysis of morphologic versus r-CBF defect size after acute stroke are described. How brain SPECT scans conducted during Diamox initiated cerebrovascular stress tests can complement the information obtained from baseline studies and assist in the interpretation of r-CBF abnormalities is also demonstrated.
Authors:
J M Mountz; G Deutsch; S H Khan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  18     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-03     Completed Date:  1994-03-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1067-82     Citation Subset:  IM    
Affiliation:
Division of Nuclear Medicine, University of Alabama, Birmingham Medical Center 35233.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cerebrovascular Circulation / physiology*
Cerebrovascular Disorders / diagnosis,  radiography,  radionuclide imaging*
Female
Humans
Magnetic Resonance Imaging
Male
Medical Illustration
Middle Aged
Organotechnetium Compounds / diagnostic use*
Oximes / diagnostic use*
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon*
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
R01 AG06432/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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