Document Detail


Regional callosal morphology in autism and macrocephaly.
MedLine Citation:
PMID:  18443971     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous investigations have reported decreased size of the corpus callosum (CC) in autism. However, little is known of the regional distribution of these callosal abnormalities. Additional uncertainty exists regarding the role of head size with respect to variations in callosal size in individuals with autism. This study investigated the size of the CC in 5 groups of high functioning individuals: (1) normocephalic autistic individuals; (2) autism with macrocephaly; (3) non-autistic normocephalic controls; (4) non-autistic participants with benign macrocephaly; and (5) a reading disordered (RD) group, comprised of non-autistic individuals with a deficit in reading. The CC was traced from midsaggital MRIs and the outlines partitioned into 99 equidistant width measures. Factor analysis of the 99 widths revealed 10 contiguous callosal regions. Individuals with macrocephaly (autistic and non-autistic) had larger total CC size. Regional analysis revealed a significantly larger CC midbody in macrocephaly, regardless of presence or absence of autism. Within normocephalic individuals, those with autism had a smaller CC genu and midbody than either non-autistic controls or RD individuals. These results underscore the importance of considering head size in studies of CC morphology in autism. These findings add to the literature implicating problems of interhemispheric connectivity being present in individuals with autism.
Authors:
Shirley Kilian; Warren S Brown; Bradley J Hallam; William McMahon; Jeffrey Lu; Michael Johnson; Erin D Bigler; Janet Lainhart
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Developmental neuropsychology     Volume:  33     ISSN:  1532-6942     ISO Abbreviation:  Dev Neuropsychol     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702038     Medline TA:  Dev Neuropsychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-99     Citation Subset:  IM    
Affiliation:
The Travis Research Institute, Fuller Graduate School of Psychology, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autistic Disorder / diagnosis*,  physiopathology
Brain / abnormalities*,  pathology*
Cephalometry
Child
Corpus Callosum / abnormalities*,  pathology*
Craniofacial Abnormalities / diagnosis*,  physiopathology
Dyslexia / diagnosis,  physiopathology
Female
Humans
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging*
Male
Neuropsychological Tests
Reference Values
Grant Support
ID/Acronym/Agency:
U19 HD035476/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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