Document Detail


Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants.
MedLine Citation:
PMID:  12728069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare regional brain volumes measured in term and preterm infants, and to correlate regional volumes with measures of neurodevelopmental outcome. METHODS: High-contrast, high-resolution magnetic resonance imaging scans were acquired in 10 preterm and 14 term infants who were scanned near term. The cerebrum was segmented into cortical gray matter, white matter, cerebral ventricles, subcortical gray matter, cerebellum, and brainstem. The cortical gray matter, white matter, and ventricles were further divided into specific anatomic subregions, and the volumes were compared across groups. Measures of cognitive and motor development were acquired between 18 and 20 months of corrected age. Correlations of regional brain volumes with developmental outcome were assessed in the preterm group. RESULTS: Volumes in preterm infants were reduced in parieto-occipital gray matter and increased in the midbody, occipital horn, and temporal horns of the lateral ventricles. Gray matter volumes were also less prominently reduced in the sensorimotor and inferior occipital cortices. Normal lateralization of white matter volumes were altered in the parieto-occipital region in the preterm infants, who had significantly larger left-sided and smaller right-sided structures. White matter volumes in the sensorimotor and midtemporal regions correlated strongly with measures of neurodevelopmental outcome. CONCLUSIONS: These findings of reduced volumes in sensorimotor and parieto-occipital regions in preterm infants, and the prospective correlations of regional volumes with cognitive outcome, confirm and extend findings previously reported in a cross-sectional study of 8-year-old prematurely born children. The data suggest that regional brain volumes near term are a promising marker for predicting disturbances of cognitive outcome in preterm infants. Further prospective, longitudinal studies of neonatal brain volumes and developmental indices into later childhood are required to confirm the utility of regional brain volumes as predictors of longer term outcome.
Authors:
Bradley S Peterson; Adam W Anderson; Richard Ehrenkranz; Lawrence H Staib; Magdi Tageldin; Eve Colson; John C Gore; Charles C Duncan; Robert Makuch; Laura R Ment
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  111     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-02     Completed Date:  2003-05-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  939-48     Citation Subset:  AIM; IM    
Affiliation:
Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA. petersob@child.cpmc.columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Anatomy, Cross-Sectional / methods,  statistics & numerical data
Brain / anatomy & histology*,  growth & development
Central Nervous System / anatomy & histology,  growth & development*
Child Development / physiology
Echo-Planar Imaging / methods,  statistics & numerical data
Female
Humans
Imaging, Three-Dimensional / methods,  statistics & numerical data
Infant
Infant, Newborn
Infant, Premature / growth & development*,  physiology
Longitudinal Studies
Male
Prospective Studies
Grant Support
ID/Acronym/Agency:
MH01232/MH/NIMH NIH HHS; MH59139/MH/NIMH NIH HHS; NS 27116/NS/NINDS NIH HHS; NS 42027/NS/NINDS NIH HHS; RR 06022/RR/NCRR NIH HHS
Comments/Corrections
Comment In:
Pediatrics. 2003 Jun;111(6 Pt 1):1432-3   [PMID:  12777566 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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