Document Detail


Regional brain volume reductions relate to facial dysmorphology and neurocognitive function in fetal alcohol spectrum disorders.
MedLine Citation:
PMID:  21416562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individuals with heavy prenatal alcohol exposure can experience significant deficits in cognitive and psychosocial functioning and alterations in brain structure that persist into adulthood. In this report, data from 99 participants collected across three sites (Los Angeles and San Diego, California, and Cape Town, South Africa) were analyzed to examine relationships between brain structure, neurocognitive function, facial morphology, and maternal reports of quantities of alcohol consumption during the first trimester. Across study sites, we found highly significant volume reductions in the FASD group for all of the brain regions evaluated. After correcting for scan location, age, and total brain volume, these differences remained significant in some regions of the basal ganglia and diencephalon. In alcohol-exposed subjects, we found that smaller palpebral fissures were significantly associated with reduced volumes in the ventral diencephalon bilaterally, that greater dysmorphology of the philtrum predicted smaller volumes in basal ganglia and diencephalic structures, and that lower IQ scores were associated with both smaller basal ganglia volumes and greater facial dysmorphology. In subjects from South Africa, we found a significant negative correlation between intracranial volume and total number of drinks per week in the first trimester. These results corroborate previous reports that prenatal alcohol exposure is particularly toxic to basal ganglia and diencephalic structures. We extend previous findings by illustrating relationships between specific measures of facial dysmorphology and the volumes of particular subcortical structures, and for the first time show that continuous measures of maternal alcohol consumption during the first trimester relates to overall brain volume reduction.
Authors:
Florence F Roussotte; Kathleen K Sulik; Sarah N Mattson; Edward P Riley; Kenneth L Jones; Colleen M Adnams; Philip A May; Mary J O'Connor; Katherine L Narr; Elizabeth R Sowell
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-17
Journal Detail:
Title:  Human brain mapping     Volume:  33     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-07-18     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  920-37     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / abnormalities*
Child
Face / abnormalities*
Female
Fetal Alcohol Spectrum Disorders / pathology*
Humans
Image Interpretation, Computer-Assisted
Intellectual Disability / etiology,  pathology*
Intelligence Tests
Magnetic Resonance Imaging
Male
Microcephaly / etiology,  pathology
Pregnancy
Grant Support
ID/Acronym/Agency:
P41 RR013642/RR/NCRR NIH HHS; R01 AA015134/AA/NIAAA NIH HHS; R01 AA15134/AA/NIAAA NIH HHS; R01 DA017830/DA/NIDA NIH HHS; R01 DA017831/DA/NIDA NIH HHS; R01 HD053893/HD/NICHD NIH HHS; R01 HD053893-01/HD/NICHD NIH HHS; U01 AA011685/AA/NIAAA NIH HHS; U01 AA014834/AA/NIAAA NIH HHS; U01 AA014834/AA/NIAAA NIH HHS; U01 AA015134/AA/NIAAA NIH HHS; U01 AA017122/AA/NIAAA NIH HHS; U01 AA017122-01/AA/NIAAA NIH HHS; U24 AA014811/AA/NIAAA NIH HHS; U24AA014811/AA/NIAAA NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813/RR/NCRR NIH HHS; UO1 AA 11685/AA/NIAAA NIH HHS
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