Document Detail


Regional brain response to visual food cues is a marker of satiety that predicts food choice.
MedLine Citation:
PMID:  22990034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Neuronal processes that underlie the subjective experience of satiety after a meal are not well defined.
OBJECTIVE: We investigated how satiety alters the perception of and neural response to visual food cues.
DESIGN: Normal-weight participants (10 men, 13 women) underwent 2 fMRI scans while viewing images of high-calorie food that was previously rated as incompatible with weight loss and "fattening" and low-calorie, "nonfattening" food. After a fasting fMRI scan, participants ate a standardized breakfast and underwent reimaging at a randomly assigned time 15-300 min after breakfast to vary the degree of satiety. Measures of subjective appetite, food appeal, and ad libitum food intake (measured after the second fMRI scan) were correlated with activation by "fattening" (compared with "nonfattening") food cues in a priori regions of interest.
RESULTS: Greater hunger correlated with higher appeal ratings of "fattening" (r = 0.46, P = 0.03) but not "nonfattening" (r = -0.20, P = 0.37) foods. Fasting amygdalar activation was negatively associated with fullness (left: r = -0.52; right: r = -0.58; both P ≤ 0.01), whereas postbreakfast fullness was positively correlated with activation in the dorsal striatum (right: r = 0.44; left: r = 0.45; both P < 0.05). After breakfast, participants with greater activation in 4 regions-medial orbital frontal cortex (r = 0.49, P < 0.05), left amygdala (r = 0.49, P < 0.05), left insula (r = 0.47, P < 0.05), and nucleus accumbens (right: r = 0.57, P < 0.01; left: r = 0.43, P < 0.05)-chose buffet foods with higher fat content.
CONCLUSIONS: Postmeal satiety is shown in regional brain activation by images of high-calorie foods. Regions including the amygdala, nucleus accumbens, and dorsal striatum may alter perception of, and reduce motivation to consume, energy-rich foods, ultimately driving food choice. This trial was registered at clinicaltrials.gov as NCT01631045.
Authors:
Sonya Mehta; Susan J Melhorn; Anne Smeraglio; Vidhi Tyagi; Thomas Grabowski; Michael W Schwartz; Ellen A Schur
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-09-18
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  96     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-03-18     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  989-99     Citation Subset:  AIM; IM    
Affiliation:
Departments of Radiology and the Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01631045
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / physiology*
Choice Behavior / physiology
Eating / physiology*
Female
Food
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Regression Analysis
Satiation / physiology*
Visual Perception / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
KL2 RR025015/RR/NCRR NIH HHS; KL2 TR000421/TR/NCATS NIH HHS; P30DK017047/DK/NIDDK NIH HHS; R01 DK090320/DK/NIDDK NIH HHS; TL1 RR025016/RR/NCRR NIH HHS; TL1 TR000422/TR/NCATS NIH HHS; UL1 RR025014/RR/NCRR NIH HHS; UL1 TR000423/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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