| Regional brain response to visual food cues is a marker of satiety that predicts food choice. | |
| | |
MedLine Citation:
|
PMID: 22990034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Neuronal processes that underlie the subjective experience of satiety after a meal are not well defined. OBJECTIVE: We investigated how satiety alters the perception of and neural response to visual food cues. DESIGN: Normal-weight participants (10 men, 13 women) underwent 2 fMRI scans while viewing images of high-calorie food that was previously rated as incompatible with weight loss and "fattening" and low-calorie, "nonfattening" food. After a fasting fMRI scan, participants ate a standardized breakfast and underwent reimaging at a randomly assigned time 15-300 min after breakfast to vary the degree of satiety. Measures of subjective appetite, food appeal, and ad libitum food intake (measured after the second fMRI scan) were correlated with activation by "fattening" (compared with "nonfattening") food cues in a priori regions of interest. RESULTS: Greater hunger correlated with higher appeal ratings of "fattening" (r = 0.46, P = 0.03) but not "nonfattening" (r = -0.20, P = 0.37) foods. Fasting amygdalar activation was negatively associated with fullness (left: r = -0.52; right: r = -0.58; both P ≤ 0.01), whereas postbreakfast fullness was positively correlated with activation in the dorsal striatum (right: r = 0.44; left: r = 0.45; both P < 0.05). After breakfast, participants with greater activation in 4 regions-medial orbital frontal cortex (r = 0.49, P < 0.05), left amygdala (r = 0.49, P < 0.05), left insula (r = 0.47, P < 0.05), and nucleus accumbens (right: r = 0.57, P < 0.01; left: r = 0.43, P < 0.05)-chose buffet foods with higher fat content. CONCLUSIONS: Postmeal satiety is shown in regional brain activation by images of high-calorie foods. Regions including the amygdala, nucleus accumbens, and dorsal striatum may alter perception of, and reduce motivation to consume, energy-rich foods, ultimately driving food choice. This trial was registered at clinicaltrials.gov as NCT01631045. |
| | |
Authors:
|
Sonya Mehta; Susan J Melhorn; Anne Smeraglio; Vidhi Tyagi; Thomas Grabowski; Michael W Schwartz; Ellen A Schur |
Related Documents
:
|
23271664 - Response-food delay gradients for lever pressing and schedule-induced licking in rats. 23403584 - Allelic variation at a single gene increases food value in a drought-tolerant staple ce... 9017724 - Performance on the purdue pegboard and finger tapping by schizophrenics after mellow an... 22412814 - Ovatoxin-a and palytoxin accumulation in seafood in relation to ostreopsis cf. ovata bl... 11510684 - Eel parasite diversity and intermediate host abundance in the river rhine, germany. 6850424 - Investigation of white-rot fungi for the conversion of poplar into a potential feedstuf... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2012-09-18 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 96 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-10-22 Completed Date: 2013-03-18 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 989-99 Citation Subset: AIM; IM |
Affiliation:
|
Departments of Radiology and the Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT01631045 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Brain / physiology* Choice Behavior / physiology Eating / physiology* Female Food Humans Magnetic Resonance Imaging / methods Male Middle Aged Regression Analysis Satiation / physiology* Visual Perception / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
KL2 RR025015/RR/NCRR NIH HHS; KL2 TR000421/TR/NCATS NIH HHS; P30DK017047/DK/NIDDK NIH HHS; TL1 RR025016/RR/NCRR NIH HHS; TL1 TR000422/TR/NCATS NIH HHS; UL1 RR025014/RR/NCRR NIH HHS; UL1 TR000423/TR/NCATS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differ...
Next Document: Calcium administration during cardiac arrest: a systematic review.