Document Detail

Regional brain glucose metabolism: correlations to biochemical measures and anxiety in patients with schizophrenia.
MedLine Citation:
PMID:  1722339     Owner:  NLM     Status:  MEDLINE    
Regional brain glucose metabolism in 20 patients with schizophrenia (DSM-III) was investigated by positron emission tomography (PET) with uniformly labeled 11C-glucose as the tracer. Monoamine metabolites were analyzed in cerebrospinal fluid (CSF) and serum, and prolactin was analyzed in serum. Intensity of anxiety was rated directly after the PET study. Ten healthy volunteers served as controls. In the patients, weak positive and negative relationships were found between homovanillic acid in CSF and prolactin in serum, respectively, and regional metabolic rates. In all subjects, positive correlations were found between the level of anxiety and the regional glucose metabolism. In the controls, positive correlations were found between anxiety and the frontal/parietal ratios of the left hemisphere, whereas anxiety scores of the patients correlated negatively to relative metabolic rates of the right medial frontal cortex and the left thalamus. These observations may indicate alterations in the neuronal systems participating in the initiation of anxiety and arousal in schizophrenia.
G Wik; F A Wiesel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  40     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-10     Completed Date:  1992-02-10     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  101-14     Citation Subset:  IM    
Department of Psychiatry and Psychology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Anxiety / physiopathology,  radionuclide imaging
Arousal / physiology
Blood Glucose / metabolism*
Brain / physiopathology,  radionuclide imaging
Brain Mapping
Dominance, Cerebral / physiology
Energy Metabolism / physiology*
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Prolactin / blood
Reference Values
Schizophrenia / physiopathology,  radionuclide imaging*
Schizophrenic Psychology*
Tomography, Emission-Computed*
Reg. No./Substance:
0/Blood Glucose; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 9002-62-4/Prolactin
Erratum In:
Psychiatry Res 1992 May;45(1):65

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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