Document Detail


Regional brain development in serial magnetic resonance imaging of low-risk preterm infants.
MedLine Citation:
PMID:  16818545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: MRI studies have shown that preterm infants with brain injury have altered brain tissue volumes. Investigation of preterm infants without brain injury offers the opportunity to define the influence of early birth on brain development and provide normative data to assess effects of adverse conditions on the preterm brain. In this study, we investigated serial MRI of low-risk preterm infants with the aim to identify regions of altered brain development. METHODS: Twenty-three preterm infants appropriate for gestational age without magnetic resonance-visible brain injury underwent MRI twice at 32 and at 42 weeks' postmenstrual age. Fifteen term infants were scanned 2 weeks after birth. Brain tissue classification and parcellation were conducted to allow comparison of regional brain tissue volumes. Longitudinal brain growth was assessed from preterm infants' serial scans. RESULTS: At 42 weeks' postmenstrual age, gray matter volumes were not different between preterm and term infants. Myelinated white matter was decreased, as were unmyelinated white matter volumes in the region including the central gyri. The gray matter proportion of the brain parenchyma constituted 30% and 37% at 32 and 42 weeks' postmenstrual age, respectively. CONCLUSIONS: This MRI study of preterm infants appropriate for gestational age and without brain injury establishes the influence of early birth on brain development. No decreased cortical gray matter volumes were found, which is in contrast to findings in preterm infants with brain injury. Moderately decreased white matter volumes suggest an adverse influence of early birth on white matter development. We identified a sharp increase in cortical gray matter volume in preterm infants' serial data, which may correspond to a critical period for cortical development.
Authors:
Andrea U J Mewes; Petra S Hüppi; Heidelise Als; Frank J Rybicki; Terrie E Inder; Gloria B McAnulty; Robert V Mulkern; Richard L Robertson; Michael J Rivkin; Simon K Warfield
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  118     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-33     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, Massachusetts 02115, USA. mewes@bwh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Brain / growth & development*,  pathology*
Cerebellum / pathology
Cerebral Cortex / pathology
Gestational Age
Humans
Image Processing, Computer-Assisted
Infant, Newborn
Infant, Premature*
Magnetic Resonance Imaging*
Grant Support
ID/Acronym/Agency:
P30 HD18655/HD/NICHD NIH HHS; P41 RR13218/RR/NCRR NIH HHS; R01 HD38261/HD/NICHD NIH HHS; R01 LM007861/LM/NLM NIH HHS; R21 MH67054/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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