Document Detail

Regional brain chemical alterations in young children with autism spectrum disorder.
MedLine Citation:
PMID:  12525726     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The authors evaluated regional brain chemistry for evidence of increased neuronal packing density in autism. METHODS: Forty-five 3- to 4-year-old children with autism spectrum disorder (ASD), 13 children with typical development (TD), and 15 children with delayed development (DD) were studied using dual-echo proton echoplanar spectroscopic imaging (32 x 32 matrix-1 cm(3) voxels) to measure brain chemical concentrations and relaxation times. Chemical quantification was corrected for tissue partial volume and relative measures of chemical relaxation (T(2r)) were calculated from the paired echoes. Measures from averaged and individual regions were compared using analysis of variance corrected for multiple comparisons. RESULTS: ASD subjects demonstrated reduced N-acetylaspartate (NAA) (-10%), creatine (Cre) (-8%), and myo-inositol (-13%) concentrations compared to TD controls and prolonged NAA T(2r) relative to TD (7%) and DD (9%) groups. Compared to DD subjects, children with ASD also demonstrated prolonged T(2r) for choline (10%) and Cre (9%). Regional analyses demonstrated subtle patterns of chemical alterations in ASD compared to the TD and DD groups. CONCLUSIONS: Brain chemical abnormalities are present in ASD at 3 to 4 years of age. However, the direction and widespread distribution of these abnormalities do not support hypothesis of diffuse increased neuronal packing density in ASD.
S D Friedman; D W Shaw; A A Artru; T L Richards; J Gardner; G Dawson; S Posse; S R Dager
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  60     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-14     Completed Date:  2003-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-7     Citation Subset:  AIM; IM    
Department of Radiology, University of Washington School of Medicine, Seattle 98105-6099, USA.
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MeSH Terms
Age Distribution
Age Factors
Aspartic Acid / analogs & derivatives*,  analysis,  metabolism*
Autistic Disorder / metabolism*
Brain / anatomy & histology,  metabolism*
Cell Count
Child, Preschool
Choline / analysis,  metabolism
Creatine / analysis,  metabolism*
Developmental Disabilities / metabolism*
Echo-Planar Imaging
Inositol / analysis,  metabolism*
Neurons / metabolism
Neuropsychological Tests
Reference Values
Sex Distribution
Grant Support
Reg. No./Substance:
56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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