| Regional brain chemical alterations in young children with autism spectrum disorder. | |
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MedLine Citation:
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PMID: 12525726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The authors evaluated regional brain chemistry for evidence of increased neuronal packing density in autism. METHODS: Forty-five 3- to 4-year-old children with autism spectrum disorder (ASD), 13 children with typical development (TD), and 15 children with delayed development (DD) were studied using dual-echo proton echoplanar spectroscopic imaging (32 x 32 matrix-1 cm(3) voxels) to measure brain chemical concentrations and relaxation times. Chemical quantification was corrected for tissue partial volume and relative measures of chemical relaxation (T(2r)) were calculated from the paired echoes. Measures from averaged and individual regions were compared using analysis of variance corrected for multiple comparisons. RESULTS: ASD subjects demonstrated reduced N-acetylaspartate (NAA) (-10%), creatine (Cre) (-8%), and myo-inositol (-13%) concentrations compared to TD controls and prolonged NAA T(2r) relative to TD (7%) and DD (9%) groups. Compared to DD subjects, children with ASD also demonstrated prolonged T(2r) for choline (10%) and Cre (9%). Regional analyses demonstrated subtle patterns of chemical alterations in ASD compared to the TD and DD groups. CONCLUSIONS: Brain chemical abnormalities are present in ASD at 3 to 4 years of age. However, the direction and widespread distribution of these abnormalities do not support hypothesis of diffuse increased neuronal packing density in ASD. |
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Authors:
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S D Friedman; D W Shaw; A A Artru; T L Richards; J Gardner; G Dawson; S Posse; S R Dager |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 60 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-14 Completed Date: 2003-01-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 100-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Washington School of Medicine, Seattle 98105-6099, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Distribution Age Factors Aspartic Acid / analogs & derivatives*, analysis, metabolism* Autistic Disorder / metabolism* Brain / anatomy & histology, metabolism* Cell Count Child, Preschool Choline / analysis, metabolism Creatine / analysis, metabolism* Developmental Disabilities / metabolism* Echo-Planar Imaging Female Humans Inositol / analysis, metabolism* Male Neurons / metabolism Neuropsychological Tests Reference Values Sex Distribution |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD34565/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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