Document Detail

Regional brain ascorbic acid distribution: its functional relationship to appetite and leptazol-induced convulsions in guinea-pigs.
MedLine Citation:
PMID:  7390716     Owner:  NLM     Status:  MEDLINE    
The distribution of ascorbic acid has been compared in the fore-, mid- and hind-brains of guinea-pigs maintained on a scorbutogenic diet alone, or the diet with supplementary Vitamin C, or the supplemented diet and a terminal convulsant dose of leptazol after 27 days. At the beginning of the investigation, mid-brain ascorbic acid concentrations were similar in both sexes and highest in the mid-brain. After 27 days on the supplemented diet, levels of ascorbic acid were raised in all three brain sections and were still highest in the mid-brains. In the scorbutic group, ascorbic acid concentrations had not changed from control levels in the mid-brain, but had fallen in the other two sections. In a dose-range of 40-60 mg/kg, leptazol caused an increase in convulsive index, and progressive depletion of brain ascorbic acid. No change occurred in fore-brain ascorbic acid, a reduction took place in the hindbrain, and the greatest fall occurred in the mid-brain. It is concluded that ascorbic acid plays an essential role in mid-brain metabolism, and that the convulsant effect of leptazol is influenced by an interaction with brain ascorbic acid.
A Odumosu; C W Wilson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  50     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  52-60     Citation Subset:  IM    
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MeSH Terms
Appetite Regulation / drug effects*
Ascorbic Acid / physiology*
Ascorbic Acid Deficiency / metabolism
Brain / anatomy & histology,  metabolism*
Dose-Response Relationship, Drug
Guinea Pigs / metabolism*
Seizures / chemically induced,  metabolism*
Sex Factors
Reg. No./Substance:
50-81-7/Ascorbic Acid; 54-95-5/Pentylenetetrazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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